ArticleProceedings of the National Academy of Sciences of the United States of America2011
Design, synthesis, and biological evaluation of a biyouyanagin compound library.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Crystal Structures of d-Lyxono-1,4-lactone and ItsMolecules (Basel, Switzerland) · 2025Article
- Characteristic metabolites of Hypericum plants: their chemical structures and biological activities.Journal of natural medicines · 2021Review
- A Review of the Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones.International journal of molecular sciences · 2021Review
- Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine.Natural product reports · 2020Review
- Spirocyclic Motifs in Natural Products.Molecules (Basel, Switzerland) · 2019Review
- Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones.Nature communications · 2018Article
- Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.BMC cancer · 2016Article
- Highlights in antiviral drug research: antivirals at the horizon.Medicinal research reviews · 2013Review
- A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction.Molecules (Basel, Switzerland) · 2013Article
- Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation.Molecular diversity · 2013Article
- Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Chemical Society reviews · 2012Review
- Bio-inspired synthesis and biological evaluation of a colchicine-related compound library.Bioorganic & medicinal chemistry letters · 2012Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted natural products, whose promising biological properties provide the motivation. Specifically, the present study targeted the naturally occurring biyouyanagins A and B and their analogs through modular chemical synthesis and led to the discovery of small organic molecules possessing anti-HIV and anti-arenavirus properties.
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Registered trials
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