ArticleThe American journal of psychiatry2011
Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients.
Article in The American journal of psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.BMC medicine · 2024Article
- Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.Nature genetics · 2023Article
- Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia.Frontiers in cellular neuroscience · 2023Article
- Effect of Gender on Development of Hippocampal Subregions From Childhood to Adulthood.Frontiers in human neuroscience · 2020Article
- 7 T MRI reveals hippocampal structural abnormalities associated with memory intrusions in childhood-onset schizophrenia.Schizophrenia research · 2018Article
- Hippocampal Subregions Across the Psychosis Spectrum.Schizophrenia bulletin · 2018Article
- Longitudinal development of hippocampal subregions from childhood to adulthood.Developmental cognitive neuroscience · 2018Article
- Hippocampal CA3-dentate gyrus volume uniquely linked to improvement in associative memory from childhood to adulthood.NeuroImage · 2017Article
- Progression from selective to general involvement of hippocampal subfields in schizophrenia.Molecular psychiatry · 2017Article
- Adult Neurogenesis and Psychiatric Disorders.Cold Spring Harbor perspectives in biology · 2016Review
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Article
- Subregional Hippocampal Morphology and Psychiatric Outcome in Adolescents Who Were Born Very Preterm and at Term.PloS one · 2015Article
- A comparison of neuroimaging findings in childhood onset schizophrenia and autism spectrum disorder: a review of the literature.Frontiers in psychiatry · 2013Review
- A family affair: brain abnormalities in siblings of patients with schizophrenia.Brain : a journal of neurology · 2013Review
- Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Article
- Article
- Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings.Psychiatry research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivePrevious anatomic studies have established a reduction in hippocampal volume in schizophrenia, but few have investigated the progressive course of these changes and whether they are trait markers. In the present study, the authors examined hippocampal volumes in relation to age for patients with childhood-onset schizophrenia, their nonpsychotic healthy siblings, and healthy comparison subjects.
methodAnatomic brain magnetic resonance scans were obtained in childhood-onset schizophrenia probands (N=89, 198 scans), their nonpsychotic full siblings (N=78, 172 scans), and matched healthy comparison subjects (N=79, 198 scans) between the ages of 10 and 29 years. Total, left, and right hippocampal volumes were measured using FreeSurfer software and analyzed using a linear mixed-model regression covarying for sex and intracranial volume.
resultsChildhood-onset schizophrenia probands had a fixed reduction in hippocampal volumes (total, left, and right) relative to both nonpsychotic siblings and healthy comparison subjects, whereas there were no significant volumetric or trajectory differences between nonpsychotic siblings and healthy comparison subjects.
conclusionsFixed hippocampal volume loss seen in childhood-onset schizophrenia, which is not shared by healthy siblings, appears to be related to the illness. Decreased hippocampal volume is not strongly genetically related but represents an important intermediate disease phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.