ArticleBiophysical journal2011
Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- One must reconstitute the functions of interest from purified proteins.Frontiers in physiology · 2024Review
- Loss of Unconventional Myosin VI Affects cAMP/PKA Signaling in Hindlimb Skeletal Muscle in an Age-Dependent Manner.Frontiers in physiology · 2022Article
- Processivity and Velocity for Motors Stepping on Periodic Tracks.Biophysical journal · 2020Article
- The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility.Biophysical journal · 2018Article
- Controllable molecular motors engineered from myosin and RNA.Nature nanotechnology · 2018Article
- Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.Nucleus (Austin, Tex.) · 2018Article
- Article
- Reexamining the origin of the directionality of myosin V.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Kinematics of the lever arm swing in myosin VI.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Kinetic Adaptations of Myosins for Their Diverse Cellular Functions.Traffic (Copenhagen, Denmark) · 2016Review
- Various Themes of Myosin Regulation.Journal of molecular biology · 2016Review
- Myosin VI deafness mutation prevents the initiation of processive runs on actin.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The winch model can explain both coordinated and uncoordinated stepping of cytoplasmic dynein.Biophysical journal · 2014Article
- Engineering myosins for long-range transport on actin filaments.Nature nanotechnology · 2014Article
- Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics.Nature reviews. Neuroscience · 2013Review
- Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC).Optics express · 2013Article
- Dualities in the analysis of phage DNA packaging motors.Bacteriophage · 2012Article
- Tuning multiple motor travel via single motor velocity.Traffic (Copenhagen, Denmark) · 2012Article
- Bayesian approach to MSD-based analysis of particle motion in live cells.Biophysical journal · 2012Article
- ATP binding controls distinct structural transitions of Escherichia coli DNA gyrase in complex with DNA.Nature structural & molecular biology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Dimeric myosin VI moves processively hand-over-hand along actin filaments. We have characterized the mechanism of this processive motion by measuring the impact of structural and chemical perturbations on single-molecule processivity. Processivity is maintained despite major alterations in lever arm structure, including replacement of light chain binding regions and elimination of the medial tail. We present kinetic models that can explain the ATP concentration-dependent processivities of myosin VI constructs containing either native or artificial lever arms. We conclude that detailed tuning of structure and intramolecular communication are dispensable for processive motion, and further show theoretically that one proposed type of nucleotide gating can be detrimental rather than beneficial for myosin processivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.