ArticleBiophysical journal2011
A simple thermodynamic model of the liquid-ordered state and the interactions between phospholipids and cholesterol.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Does Complexation of Plasma Membrane Cholesterol with Phospholipids Determine its Transbilayer Distribution?The Journal of membrane biology · 2026Article
- Gadolinium Effects on Liposome Fluidity and Size Depend on the Headgroup and Side Chain Structure of Key Mammalian Brain Lipids.Molecules (Basel, Switzerland) · 2023Article
- Laterally Resolved Small-Angle Scattering Intensity from Lipid Bilayer Simulations: An Exact and a Limited-Range Treatment.Journal of chemical theory and computation · 2020Article
- Ions Modulate Stress-Induced Nanotexture in Supported Fluid Lipid Bilayers.Biophysical journal · 2017Article
- Nanoscale Membrane Domain Formation Driven by Cholesterol.Scientific reports · 2017Article
- Hysteresis and the Cholesterol Dependent Phase Transition in Binary Lipid Mixtures with the Martini Model.The journal of physical chemistry. B · 2016Article
- GUVs melt like LUVs: the large heat capacity of MLVs is not due to large size or small curvature.Biophysical journal · 2015Article
- Differential effect of plant lipids on membrane organization: specificities of phytosphingolipids and phytosterols.The Journal of biological chemistry · 2015Article
- Phase transitions in coarse-grained lipid bilayers containing cholesterol by molecular dynamics simulations.Biophysical journal · 2012Article
- Sorting of lipidated peptides in fluid bilayers: a molecular-level investigation.Journal of the American Chemical Society · 2012Article
- Phase separation and fluctuations in mixtures of a saturated and an unsaturated phospholipid.Biophysical journal · 2012Article
- Monte Carlo simulation of protein-induced lipid demixing in a membrane with interactions derived from experiment.Biophysical journal · 2011Article
- High-throughput screening of drug-lipid membrane interactions via counter-propagating second harmonic generation imaging.Analytical chemistry · 2011Article
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Abstract
A theoretical model is proposed to describe the heat capacity function and the phase behavior of binary mixtures of phospholipids and cholesterol. The central idea is that the liquid-ordered state (L(o)) is a thermodynamic state or an ensemble of conformations of the phospholipid, characterized by enthalpy and entropy functions that are intermediate between those of the solid and the liquid-disordered (L(d)) states. The values of those thermodynamic functions are such that the L(o) state is not appreciably populated in the pure phospholipid, at any temperature, because either the solid or the L(d) state have much lower free energies. Cholesterol stabilizes the L(o) state by nearest-neighbor interactions, giving rise to the appearance of the L(o) phase. The model is studied by Monte Carlo simulations on a lattice with nearest-neighbor interactions, which are derived from experiment as much as possible. The calculated heat capacity function closely resembles that obtained by calorimetry. The phase behavior produced by the model is also in agreement with experimental data. The simulations indicate that separation between solid and L(o) phases occurs below the melting temperature of the phospholipid (T(m)). Above T(m), small L(d) and L(o) domains do exist, but there is no phase separation.
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