ArticleBiophysical journal2011
The role of stretching in slow axonal transport.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Peripheral Nerve Responses to Muscle Stretching: A Systematic Review.Journal of sports science & medicine · 2021Pooled it
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Growth and elongation of axons through mechanical tension mediated by fluorescent-magnetic bifunctional FeJournal of nanobiotechnology · 2020Article
- Effect of Cyclic Stretch on Neuron Reorientation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2020Article
- Non-invasive Neurite Mechanics in Differentiated PC12 Cells.Frontiers in cellular neuroscience · 2018Article
- An Integrated Cytoskeletal Model of Neurite Outgrowth.Frontiers in cellular neuroscience · 2018Review
- Neurite elongation is highly correlated with bulk forward translocation of microtubules.Scientific reports · 2017Article
- A model for stretch growth of neurons.Journal of biomechanics · 2016Article
- Quantifying mechanical force in axonal growth and guidance.Frontiers in cellular neuroscience · 2015Review
- Measurement of tension release during laser induced axon lesion to evaluate axonal adhesion to the substrate at piconewton and millisecond resolution.Journal of visualized experiments : JoVE · 2013Article
- Mechanical tension modulates local and global vesicle dynamics in neurons.Cellular and molecular bioengineering · 2012Article
- The emerging role of forces in axonal elongation.Progress in neurobiology · 2011Review
- The formation of actin waves during regeneration after axonal lesion is enhanced by BDNF.Scientific reports · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonal stretching is linked to rapid rates of axonal elongation. Yet the impact of stretching on elongation and slow axonal transport is unclear. Here, we develop a mathematical model of slow axonal transport that incorporates the rate of axonal elongation, protein half-life, protein density, adhesion strength, and axonal viscosity to quantify the effects of axonal stretching. We find that under conditions where the axon (or nerve) is free of a substrate and lengthens at rapid rates (>4 mm day⁻¹), stretching can account for almost 50% of total anterograde axonal transport. These results suggest that it is possible to accelerate elongation and transport simultaneously by increasing either the axon's susceptibility to stretching or the forces that induce stretching. To our knowledge, this work is the first to incorporate the effects of stretching in a model of slow axonal transport. It has relevance to our understanding of neurite outgrowth during development and peripheral nerve regeneration after trauma, and hence to the development of treatments for spinal cord injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.