ArticleLipids in health and disease2011
E2 allele of the apolipoprotein E gene polymorphism is predictive for obesity status in Roma minority population of Croatia.
Article in Lipids in health and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.PloS one · 2017Trial
- Review
- The interplay of APOE and APOA1 gene polymorphisms modulates the risk of type 2 diabetes mellitus in an obese population: a case-control study".European journal of medical research · 2026Article
- High long-term mortality in ischaemic heart disease accentuated among ethnic minorities in Eastern Europe: findings from a prospective all-comers percutaneous coronary intervention registry in Romania.Journal of epidemiology and community health · 2025Article
- Insights into the roles of Apolipoprotein E in adipocyte biology and obesity.International journal of obesity (2005) · 2024Review
- The independent association between 25 (OH) vitamin D deficiency, HOMA-IR, and lipid profile with APOE genotyping in obese cases with and without T2DM.Diabetology & metabolic syndrome · 2024Article
- Protective Association of APOC1/rs4420638 with Risk of Obesity: A case-control Study in Portuguese Children.Biochemical genetics · 2024Article
- Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations.International journal of molecular sciences · 2023Article
- Article
- Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases.International journal of molecular sciences · 2022Review
- Association betweenInternational journal of molecular sciences · 2022Article
- Influence ofHeliyon · 2021Article
- Lack of association between genetic variants in the 19q13.32 region and CHD risk in the Algerian population: a population-based nested case-control study.African health sciences · 2020Article
- Beyond the CNS: The many peripheral roles of APOE.Neurobiology of disease · 2020Review
- Phenotype and genotype predictors of BMI variability among European adults.Nutrition & diabetes · 2018Article
- Article
- The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.Journal of physiological anthropology · 2017Review
- In response to 'Comment on: "Anthropometric parameters in relation to glycaemic status and lipid profile in a multi-ethnic sample in Italy" by Gualdi-Russo et al.'.Public health nutrition · 2016Article
- Anthropometric parameters in relation to glycaemic status and lipid profile in a multi-ethnic sample in Italy.Public health nutrition · 2015Article
- Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content.Lipids in health and disease · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe Roma (Gypsies) are a transnational minority, founder population characterized by unique genetic background modeled by culturally determined endogamy. The present study explores whether the widely found cardiovascular diseases (CVD) risk effects of ACE I/D, APOE (ε2, ε3, ε4), eNOS-VNTR and LEP G2548A polymorphisms can be replicated in this specific population. METHODS AND
resultsThe community-based study was carried on 208 adult Bayash Roma living in rural settlements of eastern and northern Croatia. Risk effect of four CVD candidate polymorphisms are related to the most prominent classical CVD risk phenotypes: obesity indicators (body mass index and waist circumference), hypertension and hyperlipidemia (triglycerides, HDL and LDL cholesterol). For all of them the standard risk cut-offs were applied. The extent to which the phenotypic status is related to genotype was assessed by logistic regression analysis. The strongest associations were found for ε2 allele of the APOE as a predictor of waist circumference (OR 3.301; 95%CI 1.254-8.688; p = 0.016) as well as for BMI (OR 3.547; 95%CI 1.471-8.557; p = 0.005). It is notable that ε3 allele of APOE gene turned out to be a protective genetic factor determining low lipid levels.
conclusionThe strength of the relation and the similarity of the results obtained for both tested indicators of obesity provide firm evidence that APOE plays an important role in obesity development in the Roma population.
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