ArticleGenome biology2011
Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
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- VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.Nature communications · 2020Article
- Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.PloS one · 2017Article
- Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.Genome medicine · 2016Article
- Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer.Cell reports · 2016Article
- Molecular and genetic inflammation networks in major human diseases.Molecular bioSystems · 2016Review
- HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis.Frontiers in oncology · 2016Review
- Statistical thermodynamics of transcription profiles in normal development and tumorigeneses in cohorts of patients.European biophysics journal : EBJ · 2015Article
- Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.Nature medicine · 2015Article
- Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.Nature medicine · 2015Article
- Equalizer reduces SNP bias in Affymetrix microarrays.BMC bioinformatics · 2015Article
- The developing story of Sprouty and cancer.Cancer metastasis reviews · 2014Review
- Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.The Journal of investigative dermatology · 2014Article
- Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.The American journal of pathology · 2014Article
- A network perspective on unraveling the role of TRP channels in biology and disease.Pflugers Archiv : European journal of physiology · 2014Review
- Systematic genetic analysis identifies Cis-eQTL target genes associated with glioblastoma patient survival.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGermline polymorphisms can influence gene expression networks in normal mammalian tissues and can affect disease susceptibility. We and others have shown that analysis of this genetic architecture can identify single genes and whole pathways that influence complex traits, including inflammation and cancer susceptibility. Whether germline variants affect gene expression in tumors that have undergone somatic alterations, and the extent to which these variants influence tumor progression, is unknown.
resultsUsing an integrated linkage and genomic analysis of a mouse model of skin cancer that produces both benign tumors and malignant carcinomas, we document major changes in germline control of gene expression during skin tumor development resulting from cell selection, somatic genetic events, and changes in the tumor microenvironment. The number of significant expression quantitative trait loci (eQTL) is progressively reduced in benign and malignant skin tumors when compared to normal skin. However, novel tumor-specific eQTL are detected for several genes associated with tumor susceptibility, including IL18 (Il18), Granzyme E (Gzme), Sprouty homolog 2 (Spry2), and Mitogen-activated protein kinase kinase 4 (Map2k4).
conclusionsWe conclude that the genetic architecture is substantially altered in tumors, and that eQTL analysis of tumors can identify host factors that influence the tumor microenvironment, mitogen-activated protein (MAP) kinase signaling, and cancer susceptibility.
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