ArticleJournal of neurochemistry2011
An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in subdomains of the rat striatum: a possible role of transporter-mediated dopamine efflux.
Article in Journal of neurochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry.ACS omega · 2024Article
- In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum.Analytical and bioanalytical chemistry · 2021Article
- Experimental Methods for Investigating Uptake 2 Processes In Vivo.Handbook of experimental pharmacology · 2021Review
- Long-term dopamine neurochemical monitoring in primates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Kinetic diversity of dopamine transmission in the dorsal striatum.Journal of neurochemistry · 2015Article
- A novel restricted diffusion model of evoked dopamine.ACS chemical neuroscience · 2014Review
- Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo.Journal of neurochemistry · 2014Article
- Region- and domain-dependent action of nomifensine.The European journal of neuroscience · 2014Article
- The dopamine patchwork of the rat nucleus accumbens core.The European journal of neuroscience · 2013Article
- Restricted diffusion of dopamine in the rat dorsal striatum.ACS chemical neuroscience · 2013Article
- The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens.Neuropharmacology · 2012Article
- A method for the intracranial delivery of reagents to voltammetric recording sites.Journal of neuroscience methods · 2012Article
- Domain-dependent effects of DAT inhibition in the rat dorsal striatum.Journal of neurochemistry · 2012Article
- Microdialysis probes alter presynaptic regulation of dopamine terminals in rat striatum.Journal of neuroscience methods · 2012Article
- Tonic nanomolar dopamine enables an activity-dependent phase recovery mechanism that persistently alters the maximal conductance of the hyperpolarization-activated current in a rhythmically active neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The dopaminergic terminal field in the rat striatum is compartmentalized into sub-domains that exhibit distinct dynamics of electrically evoked dopamine release. The fast striatal domains, where dopamine release is predominantly vesicular, exhibit conventional dopaminergic activity. However, vesicular dopamine release is tonically autoinhibited in the slow domains, which suggests that dopamine reaches the autoreceptors via a non-vesicular route. Hence, it appears that the domains use distinct mechanisms to regulate the basal dopamine concentration available to activate, or not, pre-synaptic autoinhibitory receptors. However, direct detection of local variations in tonic extracellular dopamine concentrations is not yet possible. So, the present study employed voltammetry to test the hypothesis that the apparent rate of dopamine clearance from the extracellular space should be domain-dependent. The apparent rate of dopamine clearance is equal to the difference in the rates of dopamine release and uptake that determine extracellular dopamine concentrations. This study confirms that the apparent rate of dopamine clearance is slower in the slow striatal domains where vesicular dopamine release is tonically autoinhibited. These findings support the view that the basal concentration in slow domains is maintained by a non-vesicular release process, possibly transporter-mediated efflux.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.