ArticleCurrent Alzheimer research2011
Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles.
Article in Current Alzheimer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study.Frontiers in aging neuroscience · 2019Pooled it
- Association of combination statin and antihypertensive therapy with reduced Alzheimer's disease and related dementia risk.PloS one · 2020Article
- Plasma cholesterol in Alzheimer's disease and frontotemporal dementia.Translational neuroscience · 2020Article
- Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance.Journal of Alzheimer's disease : JAD · 2020Article
- Association of Hypercholesterolemia with Alzheimer's Disease Pathology and Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD · 2020Article
- High exposure to statins decrease the risk of new-onset dementia: A nationwide population-based longitudinal cohort study.Medicine · 2019Observational
- Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis.Journal of Alzheimer's disease : JAD · 2019Article
- Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease.JAMA neurology · 2017Article
- Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study.Journal of Alzheimer's disease : JAD · 2017Article
- Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2016Article
- Alzheimer's disease: Unique markers for diagnosis & new treatment modalities.The Indian journal of medical research · 2015Review
- Caffeine, Through Adenosine A3 Receptor-Mediated Actions, Suppresses Amyloid-β Protein Precursor Internalization and Amyloid-β Generation.Journal of Alzheimer's disease : JAD · 2015Article
- Article
- Associations between serum cholesterol levels and cerebral amyloidosis.JAMA neurology · 2014Article
- Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer's disease.Lipids in health and disease · 2012Article
- Potential biomarkers in psychiatry: focus on the cholesterol system.Journal of cellular and molecular medicine · 2012Review
- Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: the contribution of individual differences in prefrontal volumes and systolic blood pressure.Neuropsychologia · 2012Article
- Lipids and adipokines as risk factors for Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledElevated serum total cholesterol (TC) has been considered a risk factor for Alzheimer's disease (AD), but conflicting results have confused understanding of the relationships of serum lipids to the presence of AD in the elderly.
methodsTo clarify these issues, we evaluated correlations of admission TC, low-density (LDL) and high-density (HDL)cholesterol directly with the densities of Alzheimer hallmarks--neuritic plaques (NP) and neurofibrillary tangles (NFT)--in nursing home residents (n=281).
resultsSignificant positive associations of TC and LDL with NP densities were found in both the neocortex (TC: r=0.151, p=0.013 and LDL: r=0.190, p=0.005) and the hippocampal/entorhinal (allocortical)region (TC: r=0.182, p=0.002 and LDL: r=0.203, p=0.003). Associations of HDL with NP were less strong but also significant.In contrast, after adjustment for confounders, no correlations of NFT with any lipid were significant.When subjects with any non-AD neuropathology (largely vascular) were excluded, the TC-plaque and LDL-plaque associations for the remaining "Pure AD" subgroup were consistently stronger than for the full sample. The TC- and LDL-plaque correlations were also stronger for the subgroup of 87 subjects with an APOE ε4 allele.
conclusionsThe findings indicate that serum TC and LDL levels clearly relate to densities of NP, but not to densities of NFT. The stronger associations found in the subgroup that excluded all subjects with non-AD neuropathology suggest that cerebrovascular involvement does not explain these lipid-plaque relationships. Since the associations of TC/LDL with NP were particularly stronger in ε4 carriers, varying prevalence of this allele may explain some discrepancies among prior studies.
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