ArticleCurrent Alzheimer research2011
The potential dual effects of anesthetic isoflurane on Aβ-induced apoptosis.
Article in Current Alzheimer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Inhaled General Anesthetics in Alzheimer's Disease Progression: Divergent Effects, Underlying Mechanisms, and Future Perspectives.Molecular neurobiology · 2026Review
- The antioxidative effect of STAT3 involved in cellular vulnerability to isoflurane.BMC neuroscience · 2024Article
- Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches.Journal of cellular and molecular medicine · 2024Review
- The Effects of Sevoflurane and Aβ Interaction on CA1 Dendritic Spine Dynamics and MEGF10-Related Astrocytic Synapse Engulfment.International journal of molecular sciences · 2024Article
- Apoptosis and (in) Pain-Potential Clinical Implications.Biomedicines · 2022Review
- Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia.PloS one · 2020Article
- General Anesthetic Use in Fragile X Spectrum Disorders.Journal of neurosurgical anesthesiology · 2019Review
- The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection.Molecular medicine reports · 2019Article
- Relationship between general anesthesia and Alzheimer disease: A protocol for a systematic review and meta-analysis.Medicine · 2017Article
- The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction.Neural regeneration research · 2017Review
- Persistent mitoKMolecular neurobiology · 2017Article
- Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction.Experimental and therapeutic medicine · 2016Article
- Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors.British journal of anaesthesia · 2014Article
- General anesthetics and β-amyloid protein.Progress in neuro-psychopharmacology & biological psychiatry · 2013Review
- Dual effects of neuroprotection and neurotoxicity by general anesthetics: role of intracellular calcium homeostasis.Progress in neuro-psychopharmacology & biological psychiatry · 2013Review
- Cancer prognosis: can anesthesia play a role?Anesthesiology · 2013Article
- Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore.Medical gas research · 2012Article
- Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory.Annals of neurology · 2012Article
- Memory Loss, Alzheimer's Disease and General Anesthesia: A Preoperative Concern.Journal of anesthesia & clinical research · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
β-amyloid protein (Aβ)-induced neurotoxicity is the main component of Alzheimer's disease (AD) neuropathogenesis. Inhalation anesthetics have long been considered to protect against neurotoxicity. However, recent research studies have suggested that the inhalation anesthetic isoflurane may promote neurotoxicity by inducing apoptosis and increasing Aβ levels. We therefore set out to determine whether isoflurane can induce dose- and time-dependent dual effects on Aβ-induced apoptosis: protection versus promotion. H4 human neuroglioma cells, primary neurons from naive mice, and naive mice were treated with Aβ and/or isoflurane, and levels of caspase-3 cleavage (activation), apoptosis, Bcl-2, Bax, and cytosolic calcium were determined. Here we show for the first time that the treatment with 2% isoflurane for six hours or 30 minutes potentiated, whereas the treatment with 0.5% isoflurane for six hours or 30 minutes attenuated, the Aβ-induced caspase-3 activation and apoptosis in vitro. Moreover, anesthesia with 1.4% isoflurane for two hours potentiated, whereas the anesthesia with 0.7% isoflurane for 30 minutes attenuated, the Aβ-induced caspase-3 activation in vivo. The high concentration isoflurane potentiated the Aβ-induced reduction in Bcl-2/Bax ratio and caused a robust elevation of cytosolic calcium levels. The low concentration isoflurane attenuated the Aβ-induced reduction in Bcl-2/Bax ratio and caused only a mild elevation of cytosolic calcium levels. These results suggest that isoflurane may have dual effects (protection or promotion) on Aβ-induced toxicity, which potentially act through the Bcl-2 family proteins and cytosolic calcium. These findings would lead to more systematic studies to determine the potential dual effects of anesthetics on AD-associated neurotoxicity.
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