ReviewChembiochem : a European journal of chemical biology2011
Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".
Review in Chembiochem : a European journal of chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris.Nature communications · 2025Article
- A computational structural study on the DNA-protecting role of the tardigrade-unique Dsup protein.Scientific reports · 2020Article
- HISTome2: a database of histone proteins, modifiers for multiple organisms and epidrugs.Epigenetics & chromatin · 2020Article
- Epigenetics for Clinicians from the Perspective of Pediatric Rheumatic Diseases.Current rheumatology reports · 2020Review
- Androgen-induced Epigenetic Profiles of Polycomb and Trithorax Genes in Prostate Cancer Cells.Anticancer research · 2020Article
- Recent Achievements in Characterizing the Histone Code and Approaches to Integrating Epigenomics and Systems Biology.Methods in enzymology · 2017Review
- Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum".ACS chemical biology · 2016Review
- Reading the Combinatorial Histone Language.ACS chemical biology · 2016Review
- A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks.Cold Spring Harbor perspectives in biology · 2016Review
- Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging.The Journal of biological chemistry · 2015Article
- Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.Molecular cell · 2015Article
- Therapeutic perspectives of epigenetically active nutrients.British journal of pharmacology · 2015Review
- Intrinsically disordered proteins in the nucleus of human cells.Biochemistry and biophysics reports · 2015Article
- BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle.The Journal of biological chemistry · 2015Article
- Acetyltransferase p300/CBP associated Factor (PCAF) regulates crosstalk-dependent acetylation of histone H3 by distal site recognition.ACS chemical biology · 2015Article
- EpiFactors: a comprehensive database of human epigenetic factors and complexes.Database : the journal of biological databases and curation · 2015Article
- Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response.Epigenetics & chromatin · 2015Article
- Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.Hepatology international · 2014Article
- Disordered proteinaceous machines.Chemical reviews · 2014Review
- Glucocorticoids regulate natural killer cell function epigenetically.Cellular immunology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Histone proteins organize DNA into dynamic chromatin structures and regulate processes such as transcription, repair, and replication. Control of chromatin function and structure is mediated in part by reversible post-translational modifications (PTMs) on histones. The most N-terminal region of histone H3 contains a high density of modifiable residues. Here we focus on the dynamic interplay between histone modification states on the H3 N terminus and the binding modules that recognize these states. Specifically, we discuss the effect of auxiliary modifications to H3K4unmod/me3 binding modules (specifically H3R2 methylation, H3T3 phosphorylation, and H3T6 phosphorylation). Emerging evidence suggests that histone PTMs behave less like a strict "code", but more like a "language", which better illustrates the importance of context. Using androgen-receptor-mediated gene activation as an example, we propose a model of how the combinatorial natures of PTMs on the H3 N terminus and the complexes that recognize these epigenetic modifications control gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.