Trial reportPsychopharmacology2011
Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance.
Trial report in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Involvement of the dorsal and ventral attention networks in oddball stimulus processing: a meta-analysis.Human brain mapping · 2014Pooled it
- The interaction of oxytocin and nicotine addiction on psychosocial stress: an fMRI study.Translational psychiatry · 2024Trial
- Neuronal effects of nicotine during auditory selective attention.Psychopharmacology · 2015Trial
- Effects of nicotine on social cognition, social competence and self-reported stress in schizophrenia patients and healthy controls.European archives of psychiatry and clinical neuroscience · 2013Trial
- Human brain functional network changes associated with enhanced and impaired attentional task performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Nicotinic acetylcholine receptor expression on B-lymphoblasts of healthy versus schizophrenic subjects stratified for smoking: [3H]-nicotine binding is decreased in schizophrenia and correlates with negative symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2012Trial
- Interaction Between Smoking and Internet Gaming Disorder on Spontaneous Brain Activity.Frontiers in psychiatry · 2020Article
- Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.Translational psychiatry · 2019Article
- Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers.Frontiers in human neuroscience · 2019Article
- Variance decomposition for single-subject task-based fMRI activity estimates across many sessions.NeuroImage · 2017Article
- All cravings are not created equal.Addiction (Abingdon, England) · 2015Article
- Smoking and Neuroimaging: A Review.Current cardiovascular risk reports · 2011Article
- Functional brain imaging of nicotinic effects on higher cognitive processes.Biochemical pharmacology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considerable variability across individuals has been reported in both the behavioral and fMRI blood oxygen level-dependent (BOLD) response to nicotine. We aimed to investigate (1) whether there is a heterogeneous effect of nicotine on behavioral and BOLD responses across participants and (2) if heterogeneous BOLD responses are associated with behavioral performance measures. In this double-blind, placebo-controlled, cross-over study, 41 healthy participants (19 smokers)--drawn from a larger population-based sample--performed a visual oddball task after acute challenge with 1 mg nasal nicotine. fMRI data and reaction time were recorded during performance of the task. Across the entire group of subjects, we found increased activation in the anterior cingulate cortex, middle frontal gyrus, superior temporal gyrus, post-central gyrus, planum temporal and frontal pole in the nicotine condition compared with the placebo condition. However, follow-up analyses of this difference in activation between the placebo and nicotine conditions revealed that some participants showed an increase in activation while others showed a decrease in BOLD activation from the placebo to the nicotine condition. A reduction of BOLD activation from placebo to nicotine was associated with a decrease in reaction time and reaction time variability and vice versa, suggesting that it is the direction of BOLD response to nicotine which is related to task performance. We conclude that the BOLD response to nicotine is heterogeneous and that the direction of response to nicotine should be taken into account in future pharmaco-fMRI research on the central action of nicotine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.