Evidence map›Paper›PMID 21243420›Full record

ReviewBehavior genetics2011

In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.

Thomas Skiba, Nicole Landi, Richard Wagner, Elena L Grigorenko

Abstract readReview
In one paragraph

Review in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas SkibaYale University, New Heaven, CT, USA.
Nicole Landi
Richard Wagner
Elena L Grigorenko

Funding

THE FLORIDA LONGITUDINAL STUDYP50HD052120 · NICHD · FLORIDA STATE UNIVERSITY · PI CHRIS W SCHATSCHNEIDER · 2006 to 2026
$31.7M
Genetic Bases of Developmental Language DisordersR01DC007665 · NIDCD · YALE UNIVERSITY · PI GRIGORENKO, ELENA L · 2006 to 2010
$3.0M
Reading Disabilities in Zambian ChildrenR01TW008274 · FIC · YALE UNIVERSITY · PI GRIGORENKO, ELENA L · 2008 to 2014
$1.0M
FIC NIH HHS R01 TW008274FIC NIH HHS TW008274NICHD NIH HHS HD052120NICHD NIH HHS P50 HD052120NIDCD NIH HHS DC007665NIDCD NIH HHS R01 DC007665
6 · The paper itself

Abstract

Reading ability and specific reading disability (SRD) are complex traits involving several cognitive processes and are shaped by a complex interplay of genetic and environmental forces. Linkage studies of these traits have identified several susceptibility loci. Association studies have gone further in detecting candidate genes that might underlie these signals. These results have been obtained in samples of mainly European ancestry, which vary in their languages, inclusion criteria, and phenotype assessments. Such phenotypic heterogeneity across samples makes understanding the relationship between reading (dis)ability and reading-related processes and the genetic factors difficult; in addition, it may negatively influence attempts at replication. In moving forward, the identification of preferable phenotypes for future sample collection may improve the replicability of findings. This review of all published linkage and association results from the past 15 years was conducted to determine if certain phenotypes produce more replicable and consistent results than others.

Indexed as

Genetic Association StudiesGenetic LinkagePhenotypeAchievementAttention Deficit Disorder with HyperactivityChildComorbidityCross-Cultural ComparisonDiseases in TwinsDyslexiaEducation, SpecialGenotypeHumansIntelligenceLod ScoreMental Recall

Identifiers

PMID21243420
PMCPMC3056345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.