ArticleClinical oral investigations2012
Oxidative stress and cytotoxicity generated by dental composites in human pulp cells.
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The trial behind it
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Who cites it
40 citing papers in PubMed, 122 citations in OpenAlex.
- Five-year clinical performance of a HEMA-free one-step self-etch adhesive in noncarious cervical lesions.Clinical oral investigations · 2014Trial
- Cytotoxicity of Self-Etch Versus Etch-and-Rinse Dentin Adhesives After 48 h: An In Vitro Study.Dentistry journal · 2026Article
- Cytotoxicity of hexagonal boron nitride incorporated conventional and resin modified glass ionomer cements: in vitro study.BMC oral health · 2026Article
- Physicomechanical Properties and Morphological Characterization of Several Universal Resin Composites After Different Aging Procedures.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Article
- Assessment of physicochemical properties and biological responses of chemically surface-modified microcapsules for self-healing dental restorative materials.Materials & design · 2025Article
- Review
- Estimation of Salivary Nitric Oxide Levels Following Composite Restorations in Primary Molars: AnInternational journal of clinical pediatric dentistry · 2025Article
- Article
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- Evaluation of Cytotoxicity of the Dental Materials TheraCal LC, TheraCal PT, ApaCal ART and Biodentine Used in Vital Pulp Therapy: In Vitro Study.Dentistry journal · 2024Article
- Alternative Direct Restorative Materials for Dental Amalgam: A Concise Review Based on an FDI Policy Statement.International dental journal · 2024Review
- Comparative cell viability of dentin-bonding adhesive systems on human dental pulp stem cells: time-dependent analysis.BMC oral health · 2024Article
- In Vitro Cytotoxic and Inflammatory Response of Gingival Fibroblasts and Oral Mucosal Keratinocytes to 3D Printed Oral Devices.Polymers · 2024Article
- The Management of Hyperplastic Pulpitis in Immature Permanent Molar Using Vital Pulp Therapy: A Case Report with 12 Months Follow-Up.Case reports in dentistry · 2024Article
- Cytotoxicity and reactive oxygen species production induced by different co-monomer eluted from nanohybrid dental composites.BMC oral health · 2023Article
- Characterization and In Vitro Biocompatibility of Two New Bioglasses for Application in Dental Medicine-A Preliminary Study.Materials (Basel, Switzerland) · 2022Article
- Characteristics of a novel photoinitiator aceanthrenequinone-initiated polymerization and cytocompatibility of its triggered polymer.Toxicology reports · 2022Article
- Cytotoxic and Genotoxic Effects of Composite Resins on Cultured Human Gingival Fibroblasts.Materials (Basel, Switzerland) · 2021Article
- Genotoxic and cytotoxic potential of methacrylate-based orthodontic adhesives.Clinical oral investigations · 2021Article
- Coronal Restoration as a Predictor of Periapical Disease in Non-Endodontically Treated Teeth.Acta stomatologica Croatica · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental composites are a source of residual monomers that are released into the oral environment. Since monomers act on cultured cells through reactive oxygen species (ROS), we hypothesized that composites generate ROS associated with cytotoxicity. Human pulp-derived cells were exposed to extracts of methacrylate-based materials including triethylene glycol dimethacrylate and 2-hydroxyethyl methacrylate-free composites (Tetric Ceram, Tetric EvoCeram, els, els flow, Solitaire 2) and a silorane-based composite (Hermes III). The materials were polymerized in the presence and absence of a polyester film and then extracted in culture medium. The generation of ROS was measured by flow cytometry, and cytotoxicity was determined as well. Methacrylate-based composites reduced cell survival but varied in efficiency. Undiluted extracts of Solitaire 2 specimens prepared in the absence of a polyester film reduced cell survival to 26% compared with untreated cultures. Cytotoxicity was reduced when specimens were covered with a polyester film during preparation. Cytotoxicity of the composites was ranked as follows: Solitaire 2 >> els flow > Tetric Ceram = Tetric EvoCeram = els > Hermes III. The generation of ROS followed the same pattern as detected with cytotoxic effects. A positive correlation was found between ROS production and cell survival caused by extracts made from materials not covered with a polyester film. These findings suggest that components released from composites affect cellular signaling networks through ROS formation. Regenerative and reparative capacities of the dentine-pulp complex may be impaired by biologically active resin monomers released from composite restorations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.