ArticleClinics (Sao Paulo, Brazil)2010
High rate of viral identification and coinfections in infants with acute bronchiolitis.
Article in Clinics (Sao Paulo, Brazil), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Risk Factors for Severe Bronchiolitis in Australian and Aotearoa New Zealand Infants: A Systematic Review.Journal of paediatrics and child health · 2025Pooled it
- Pooled it
- Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Pooled it
- Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis.PloS one · 2014Pooled it
- The prevalence and role of human respiratory syncytial virus in pediatric respiratory tract infections: a systematic review and meta-analysis of global data.EClinicalMedicine · 2026Article
- Respiratory Support Practices for Bronchiolitis in the Pediatric Intensive Care Unit.JAMA network open · 2024Article
- Outcomes of viral coinfections in infants hospitalized for acute bronchiolitis.Virology journal · 2023Observational
- Admissions for Bronchiolitis at Children's Hospitals Before and During the COVID-19 Pandemic.JAMA network open · 2023Article
- Co-Infection Rates between SARS-CoV-2 and RSV in Oropharyngeal, Nasopharyngeal Aspirate and Saliva Samples of COVID-19 Patients, Shiraz, South of Iran.Journal of dentistry (Shiraz, Iran) · 2023Article
- A rapid and highly sensitive multiple detection of human adenovirus type 3, type 7 and respiratory syncytial virus by recombinase-aided reverse transcription PCR.Journal of clinical laboratory analysis · 2023Article
- A cooperativity between virus and bacteria during respiratory infections.Frontiers in microbiology · 2023Review
- Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou.BMC infectious diseases · 2021Article
- Article
- Respiratory pathogen diversity and co-infections in rural Zambia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Different patterns of Influenza A and B detected during early stages of COVID-19 in a university hospital in São Paulo, Brazil.The Journal of infection · 2020Article
- Comparison of clinical features of acute lower respiratory tract infections in infants with RSV/HRV infection, and incidences of subsequent wheezing or asthma in childhood.BMC infectious diseases · 2020Article
- Recent advances in the detection of respiratory virus infection in humans.Journal of medical virology · 2020Review
- Association between multiple respiratory viral infections and pediatric intensive care unit admission among infants with bronchiolitis.Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2020Article
- Nation-wide surveillance of human acute respiratory virus infections between 2013 and 2015 in Korea.Journal of medical virology · 2018Article
- Characteristics of children admitted to intensive care with acute bronchiolitis.European journal of pediatrics · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the viruses and risk factors associated with hospital and intensive care unit (ICU) admissions in infants with acute bronchiolitis.
introductionBronchiolitis is a major cause of morbidity in infants. Widespread use of molecular-based methods has yielded new insights about its etiology, but the impact of viral etiologies on early outcomes is still unclear.
methodsSeventy-seven infants with bronchiolitis who were under two years of age and visited an emergency unit were included. Using molecular-based methods, samples were tested for 12 different respiratory viruses. Logistic regression models were used to identify clinical and virological variables associated with the main endpoints: hospital admission and ICU admission.
resultsWe identified at least one virus in 93.5% of patients, and coinfections were found in nearly 40% of patients. RSV was the most common pathogen (63.6%), followed by rhinovirus (39%). Identification of RSV was only associated with an increased risk of hospital admission in the univariate model. Younger age and enterovirus infection were associated with an increased risk of hospital admission, while atopy of a first-degree relative showed a protective effect. Prematurity was associated with an increased risk of admission to the ICU. Coinfections were not associated with worse outcomes.
conclusionsMolecular-based methods resulted in high rates of viral identification but did not change the significant role of RSV in acute bronchiolitis. Younger age and enterovirus infection were risk factors for hospital admission, while prematurity appeared to be a significant risk factor for admission to the ICU in acute viral bronchiolitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.