Evidence map›Paper›PMID 21243120›Full record

ArticleCellular therapy and transplantation2010

The role of the marrow microenvironment in hematopoietic stem cell transplantation.

Aravind Ramakrishnan, Beverly J Torok-Storb

Abstract read
In one paragraph

Article in Cellular therapy and transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Primary marrow-derived stromal cells: isolation and manipulation.Methods in molecular biology (Clifton, N.J.) · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aravind RamakrishnanFred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA.
Beverly J Torok-Storb

Funding

CORE--VECTOR PRODUCTIONP30DK056465 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 1999 to 2014
$14.9M
Controlling Hematopoietic Lineage Commitment from ESC to PlateletsU01HL099993 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TOROK-STORB, BEVERLY J. · 2009 to 2015
$8.3M
Generating iPS cells by reprogramming using small moleculesK08DK082783 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAMAKRISHNAN, ARAVIND · 2009 to 2013
$671k
NHLBI NIH HHS U01 HL099993NIDDK NIH HHS K08 DK082783NIDDK NIH HHS P30 DK056465
6 · The paper itself

Abstract

The success of hematopoietic stem cell transplantation depends on the engraftment of pluripotent hematopoietic stem cells and the regulated proliferation and maturation of committed progenitor cells. It is generally agreed that these processes cannot occur without an appropriate milieu provided by a competent marrow microenvironment (ME). The ME is composed of both non-hematopoietic and hematopoietic stem cell derived cells and consequently is chimeric following allogeneic stem cell transplantation, containing recipient stromal cells and donor macrophages.

Identifiers

PMID21243120
PMCPMC3020088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.