ArticleMolecular physics2008
Landscape of finite-temperature equilibrium behaviour of curvature-inducing proteins on a bilayer membrane explored using a linearized elastic free energy model.
Article in Molecular physics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins.Physics reports · 2014Article
- Multiscale computational models in physical systems biology of intracellular trafficking.IET systems biology · 2014Article
- Defining the free-energy landscape of curvature-inducing proteins on membrane bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation.Journal of nanotechnology in engineering and medicine · 2013Review
- Mesoscale simulations of curvature-inducing protein partitioning on lipid bilayer membranes in the presence of mean curvature fields.Molecular physics · 2012Article
- Systems biology and physical biology of clathrin-mediated endocytosis.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Cancer Cell: Linking Oncogenic Signaling to Molecular Structure.Chapman & Hall/CRC mathematical & computational biology series · 2011Article
- Minimal mesoscale model for protein-mediated vesiculation in clathrin-dependent endocytosis.PLoS computational biology · 2010Article
- Calculation of free energies in fluid membranes subject to heterogeneous curvature fields.Physical review. E, Statistical, nonlinear, and soft matter physics · 2009Article
- Phenomenology based multiscale models as tools to understand cell membrane and organelle morphologies.Advances in planar lipid bilayers and liposomesArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Using a recently developed multiscale simulation methodology, we describe the equilibrium behaviour of bilayer membranes under the influence of curvature-inducing proteins using a linearized elastic free energy model. In particular, we describe how the cooperativity associated with a multitude of protein-membrane interactions and protein diffusion on a membrane-mediated energy landscape elicits emergent behaviour in the membrane phase. Based on our model simulations, we predict that, depending on the density of membrane-bound proteins and the degree to which a single protein molecule can induce intrinsic mean curvature in the membrane, a range of membrane phase behaviour can be observed including two different modes of vesicle-bud nucleation and repressed membrane undulations. A state diagram as a function of experimentally tunable parameters to classify the underlying states is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.