Evidence map›Paper›PMID 21243015›Full record

ReviewNature reviews. Neurology2011

Neuroplasticity in the context of motor rehabilitation after stroke.

Michael A Dimyan, Leonardo G Cohen

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 285 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
285citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04429945 nacompletednot on this mapstarted 2021, after this paper: background citation

Immersive Virtual Reality to Improve Outcomes in Patients With Stroke: A Pilot Study

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2021 to 2022Enrolled10ConditionsStrokeArmsVirtual Reality
NCT06884553 narecruitingnot on this mapstarted 2023, after this paper: background citation

Effects of Robot-assistED Rehabilitation Versus OccupatIonal Therapy on the Functional Recovery of the Upper Limb in PatiEnts with Chronic STroke: a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of FlorenceRan2023 to 2025Enrolled72ConditionsChronic StrokeArmsRobotic therapy (Gloreha Sinfonia system), Occupational therapy, Control
3 · Its place in the literature

Who cites it

285 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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225 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael A DimyanHuman Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1428, USA.
Leonardo G Cohen

Funding

Cortical reorganization and plasticity In the Healthy BrainZIANS002978 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$38.0M
Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Intramural NIH HHS ZIA NS002978
6 · The paper itself

Abstract

Approximately one-third of patients with stroke exhibit persistent disability after the initial cerebrovascular episode, with motor impairments accounting for most poststroke disability. Exercise and training have long been used to restore motor function after stroke. Better training strategies and therapies to enhance the effects of these rehabilitative protocols are currently being developed for poststroke disability. The advancement of our understanding of the neuroplastic changes associated with poststroke motor impairment and the innate mechanisms of repair is crucial to this endeavor. Pharmaceutical, biological and electrophysiological treatments that augment neuroplasticity are being explored to further extend the boundaries of poststroke rehabilitation. Potential motor rehabilitation therapies, such as stem cell therapy, exogenous tissue engineering and brain-computer interface technologies, could be integral in helping patients with stroke regain motor control. As the methods for providing motor rehabilitation change, the primary goals of poststroke rehabilitation will be driven by the activity and quality of life needs of individual patients. This Review aims to provide a focused overview of neuroplasticity associated with poststroke motor impairment, and the latest experimental interventions being developed to manipulate neuroplasticity to enhance motor rehabilitation.

Indexed as

Stroke RehabilitationExercise TherapyHumansMotor ActivityNeuronal PlasticityPersons with DisabilitiesRecovery of FunctionStroke

Identifiers

PMID21243015
PMCPMC4886719

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.