Trial reportAmerican journal of nephrology2011
Effects of sodium thiosulfate on vascular calcification in end-stage renal disease: a pilot study of feasibility, safety and efficacy.
Trial report in American journal of nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Comparative Efficacy of Interventions for Vascular Calcification and Stiffness in Dialysis Patients: A Systematic Review and Network Meta-Analysis.Cardiorenal medicine · 2026Pooled it
- Pooled it
- Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients-a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Pooled it
- Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease.American journal of nephrology · 2013Trial
- Decoding vascular calcification: mechanistic insights and translational strategies.Cellular and molecular life sciences : CMLS · 2026Review
- Effect of sodium thiosulfate on preventing renal ischemia-reperfusion injury in high-fat diet-fed rats: the role of renal mitochondrial quality.Biological research · 2025Article
- Vascular calcification: from the perspective of crosstalk.Molecular biomedicine · 2023Review
- Sodium Thiosulfate in Acute Myocardial Infarction: A Randomized Clinical Trial.JACC. Basic to translational science · 2023Article
- Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications.Journal of nephrology · 2021Article
- The roles of collagen in chronic kidney disease and vascular calcification.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Safety and Tolerability of Sodium Thiosulfate in Patients with an Acute Coronary Syndrome Undergoing Coronary Angiography: A Dose-Escalation Safety Pilot Study (SAFE-ACS).Journal of interventional cardiology · 2020Article
- Natural and non-natural antioxidative compounds: potential candidates for treatment of vascular calcification.Cell death discovery · 2019Review
- The renal mitochondrial dysfunction in patients with vascular calcification is prevented by sodium thiosulfate.International urology and nephrology · 2016Article
- Clinical imaging of vascular disease in chronic kidney disease.International urology and nephrology · 2016Review
- Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric rats.PloS one · 2015Article
- Are there ways to attenuate arterial calcification and improve cardiovascular outcomes in chronic kidney disease?World journal of cardiology · 2014Review
- Regression of vascular calcification following an acute episode of calciphylaxis: a case report.Journal of medical case reports · 2014Article
- Vascular calcification and renal bone disorders.TheScientificWorldJournal · 2014Review
- Vascular calcification: an update on mechanisms and challenges in treatment.Calcified tissue international · 2013Review
- Lowering vascular calcification burden in chronic kidney disease: Is it possible?World journal of nephrology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesVascular calcification is a major contributor to morbidity and mortality in hemodialysis. The objective of this pilot study was to determine the feasibility, safety and efficacy of sodium thiosulfate (STS) in the progression of vascular calcification in hemodialysis patients.
methodsChronic hemodialysis patients underwent a battery of cardiovascular tests. Those with coronary artery calcium (Agatston scores >50) received intravenous STS after each dialysis for 5 months (n = 22) and the tests were repeated. Changes in MDCT-determined calcification were assessed as the mean annualized rate of change in 3 vascular beds (coronary, thoracic and carotid arteries) and in L1-L2 vertebral bone density.
resultsAlthough individual analyses showed coronary artery calcification progression in 14/22 subjects, there was no progression in the mean annualized rate of change of vascular calcification in the entire group. The L1-L2 vertebral bone density showed no changes. There were no correlations between rates of progression of vascular calcification and phosphorus, fetuin or C-reactive protein levels. Changes in coronary artery calcification scores correlated with those of the thoracic aorta.
conclusionSTS treatment is feasible, appears safe and may decrease the rate of progression of vascular calcification in hemodialysis patients. A large, randomized, controlled trial is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.