ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- [Clinical features ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- NOD2-NLRP3 Axis and Asthma.Journal of asthma and allergy · 2025Review
- Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake.Scientific reports · 2023Article
- Review
- Tuning cytokines enriches dendritic cells and regulatory T cells in the periodontium.Journal of periodontology · 2020Article
- The Binary Classification Of Chronic Diseases.Journal of inflammation research · 2019Article
- FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing.The Journal of biological chemistry · 2018Article
- Donor Genotype in the Interleukin-7 Receptor α-Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2018Article
- T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways.Respiratory research · 2016Article
- Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma.Molecular therapy. Nucleic acids · 2016Article
- Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33.The Journal of allergy and clinical immunology · 2016Article
- Article
- Thymic stromal lymphopoietin signaling in CD4(+) T cells is required for TH2 memory.The Journal of allergy and clinical immunology · 2015Article
- Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs.PloS one · 2015Article
- The importance of TSLP in allergic disease and its role as a potential therapeutic target.Expert review of clinical immunology · 2014Review
- Thymic stromal lymphopoietin and cancer.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells.Frontiers in immunology · 2013Review
- Th9 cell development requires a BATF-regulated transcriptional network.The Journal of clinical investigation · 2013Article
- Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP.Immunity · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Thymic stromal lymphopoietin (TSLP) is an essential cytokine for the initiation and development of allergic inflammation. In this study, we have investigated the role of TSLP in the breakdown of immune tolerance and generation of inducible regulatory T cells (iTregs). Our results demonstrated that TSLP diverted airway tolerance against OVA to Th2 sensitization and inhibited the generation of OVA-specific iTregs. TSLP exerted a direct inhibitory effect on both human and mouse iTreg development in vitro. Low doses of TSLP were capable of inhibiting iTreg induction without significantly promoting Th2 development, indicating that these two functions of TSLP are separable. Moreover, the TSLP-mediated inhibition of iTreg generation was only partially dependent on IL-4 and Stat6, and was effective when TSLP was present for the first 24 h of T cell activation. These results define a novel role for TSLP in regulating the balance of airway tolerance and allergic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.