SynthesisNeurology2011
Adverse antiepileptic drug effects in new-onset seizures: a case-control study.
Synthesis in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03689114 (Efficacy and Tolerability of Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Tolerability of Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy (STANDLOW). A Multicenter, Randomized, Single-blind, Parallel-group Trial
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.CNS drugs · 2021Pooled it
- Trial
- Predictors of Neuropsychiatric Adverse Events with Smoking Cessation Medications in the Randomized Controlled EAGLES Trial.Journal of general internal medicine · 2019Trial
- Trial
- Development, psychometric validation, and correlates of the 15-item quality of life in epilepsy scale (QOLIE-15).Scientific reports · 2026Article
- Treatment Response to Antiseizure Medications in People With Newly Diagnosed Focal Epilepsy.JAMA neurology · 2025Observational
- Article
- Impact of depressive symptoms on adverse effects in people with epilepsy on antiseizure medication therapy.Epilepsia open · 2024Article
- Psychiatric disorders of the combination of levetiracetam either with lacosamide or perampanel: a retrospective cohort study.International journal of clinical pharmacy · 2021Article
- Evaluation of Factors Impacting the Efficacy of Single or Combination Therapies of Valproic Acid, Carbamazepine, and Oxcarbazepine: A Longitudinal Observation Study.Frontiers in pharmacology · 2021Article
- Tolerability of Antiseizure Medications in Individuals With Newly Diagnosed Epilepsy.JAMA neurology · 2020Article
- Article
- Validity of the Liverpool Adverse Events Profile as a Screening Tool for Detecting Comorbid Depression or Anxiety Disorder in People with Epilepsy.Journal of epilepsy research · 2018Article
- Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders?Epilepsy & behavior : E&B · 2017Article
- Managing an Unprovoked First Seizure in Adults.CNS drugs · 2016Review
- Article
- Medication side effects among people with epilepsy taking phenobarbital in Zambia.Epilepsy research · 2014Article
- Treatment of epilepsy in daily clinical practice: have outcomes improved over the past 10 years?Journal of neurology · 2013Article
- Research implications of the Institute of Medicine Report, Epilepsy Across the Spectrum: Promoting Health and Understanding.Epilepsia · 2013Review
- Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan.Lancet (London, England) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAdverse effects (AEs) are a major concern when starting antiepileptic drug (AED) treatment. This study quantified the extent to which AE reporting in people with new-onset seizures started on AEDs is attributable to the medication per se, and investigated variables contributing to AE reporting.
methodsWe pooled data from 2 large prospective studies, the Multicenter Study of Early Epilepsy and Single Seizures and the Northern Manhattan Study of incident unprovoked seizures, and compared adverse event profile (AEP) total and factor scores between adult cases prescribed AEDs for new-onset seizures and untreated controls, adjusting for several demographic and clinical variables. Differences in AEP scores were also tested across different AED monotherapies and controls, and between cases and controls grouped by number of seizures.
resultsA total of 212 cases and 206 controls were identified. Most cases (94.2%) were taking low AED doses. AEP scores did not differ significantly between the 2 groups. Depression, female gender, symptomatic etiology, younger seizure onset age, ≥2 seizures, and history of febrile seizures were associated with higher AEP scores. There were no significant differences in AEP scores across different monotherapies and controls. AEP scores increased in both cases and controls with increasing number of seizures, the increment being more pronounced in cases.
conclusionsWhen AED treatment is started at low doses following new-onset seizures, AE reporting does not differ from untreated individuals. Targeting specific factors affecting AE reporting could lead to improved tolerability of epilepsy treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.