ReviewCurrent opinion in pharmacology2011
Angiotensin and carotid body chemoreception in heart failure.
Review in Current opinion in pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Ventilatory response to hypercapnia is increased after 4 h of head down bed rest.Scientific reports · 2021Trial
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Carotid body dysregulation contributes to Long COVID symptoms.Communications medicine · 2024Article
- Commonalities and differences in carotid body dysfunction in hypertension and heart failure.The Journal of physiology · 2023Article
- Neurochemical Anatomy of the Mammalian Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling.Frontiers in cellular neuroscience · 2023Article
- The Role of Pharmacological Treatment in the Chemoreflex Modulation.Frontiers in physiology · 2022Review
- Causes of Hypoxemia in COVID-19.Journal of evolutionary biochemistry and physiology · 2022Article
- Are Multiple Chemosensory Systems Accountable for COVID-19 Outcome?Journal of clinical medicine · 2021Review
- Syncope and silent hypoxemia in COVID-19: Implications for the autonomic field.Autonomic neuroscience : basic & clinical · 2021Article
- ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen.Journal of neuroendocrinology · 2021Review
- Silent hypoxaemia in COVID-19 patients.The Journal of physiology · 2021Review
- The potential role of the carotid body in COVID-19.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets.International journal of molecular sciences · 2020Review
- Central AT1 receptor signaling by circulating angiotensin II is permissive to acute intermittent hypoxia-induced sympathetic neuroplasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- A Potential Role of the Renin-Angiotensin-System for Disturbances of Respiratory Chemosensitivity in Acute Respiratory Distress Syndrome and Severe Acute Respiratory Syndrome.Frontiers in physiology · 2020Article
- Activation of the hypothalamic paraventricular nucleus by acute intermittent hypoxia: Implications for sympathetic long-term facilitation neuroplasticity.Experimental neurology · 2019Article
- Effect of Chronic Intermittent Hypoxia on Angiotensin II Receptors in the Central Nervous System.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2018Article
- Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia.Respiratory physiology & neurobiology · 2016Article
- Modulation of angiotensin II signaling following exercise training in heart failure.American journal of physiology. Heart and circulatory physiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.