ArticleJournal of theoretical biology2011
Response of an actin filament network model under cyclic stretching through a coarse grained Monte Carlo approach.
Article in Journal of theoretical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells.BMC molecular and cell biology · 2024Article
- A machine learning approach to predict cellular mechanical stresses in response to chemical perturbation.Biophysical journal · 2023Article
- Rapid prediction of protein natural frequencies using graph neural networks.Digital discovery · 2022Article
- Article
- Endothelial Cells Morphology in Response to Combined WSS and Biaxial CS: Introduction of Effective Strain Ratio.Cellular and molecular bioengineering · 2020Article
- Genomics models in radiotherapy: From mechanistic to machine learning.Medical physics · 2020Review
- Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors.Lab on a chip · 2020Review
- Bioreactor With Electrically Deformable Curved Membranes for Mechanical Stimulation of Cell Cultures.Frontiers in bioengineering and biotechnology · 2020Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
- How can we predict cellular mechanosensation?: Comment on "Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses" by Bo Cheng et al.Physics of life reviews · 2017Article
- Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions.Journal of biomechanical engineering · 2017Article
- Biomechanics of cell reorientation in a three-dimensional matrix under compression.Experimental cell research · 2017Article
- Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells.Scientific reports · 2016Article
- Structurally governed cell mechanotransduction through multiscale modeling.Scientific reports · 2015Article
- Mechanoregulation of h2-calponin gene expression and the role of Notch signaling.The Journal of biological chemistry · 2014Article
- A coupled fiber-matrix model demonstrates highly inhomogeneous microstructural interactions in soft tissues under tensile load.Journal of biomechanical engineering · 2013Article
- Article
- Mechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gels.Annals of biomedical engineering · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cells are complex, dynamic systems that actively adapt to various stimuli including mechanical alterations. Central to understanding cellular response to mechanical stimulation is the organization of the cytoskeleton and its actin filament network. In this manuscript, we present a minimalistic network Monte Carlo based approach to model actin filament organization under cyclic stretching. Utilizing a coarse-grained model, a filament network is prescribed within a two-dimensional circular space through nodal connections. When cyclically stretched, the model demonstrates that a perpendicular alignment of the filaments to the direction of stretch emerges in response to nodal repositioning to minimize net nodal forces from filament stress states. In addition, the filaments in the network rearrange and redistribute themselves to reduce the overall stress by decreasing their individual stresses. In parallel, we cyclically stretch NIH 3T3 fibroblasts and find a similar cytoskeletal response. With this work, we test the hypothesis that a first-principles mechanical model of filament assembly in a confined space is by itself capable of yielding the remodeling behavior observed experimentally. Identifying minimal mechanisms sufficient to reproduce mechanical influences on cellular structure has important implications in a diversity of fields, including biology, physics, medicine, computer science, and engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.