ArticleInternational orthopaedics2011
Toxicity of antiseptics against chondrocytes: what is best for the cartilage in septic joint surgery?
Article in International orthopaedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Evaluation of the role of povidone‑iodine in the prevention of surgical site infections.Surgery open science · 2023Review
- Post-operative septic arthritis after arthroscopy: modern diagnostic and therapeutic concepts.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Review
- Sodium hypochlorite is more effective than chlorhexidine for eradication of bacterial biofilm of staphylococci and Pseudomonas aeruginosa.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Local Anesthetics' Toxicity toward Human Cultured Chondrocytes: A Comparative Study between Lidocaine, Bupivacaine, and Ropivacaine.Cartilage · 2019Article
- The downside of antimicrobial agents for wound healing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Activity of taurolidine gels on ex vivo periodontal biofilm.Clinical oral investigations · 2018Article
- [Antibiotic strategies in trauma surgery : Treatment of implant-associated infections].Der Unfallchirurg · 2017Review
- Human osteoblast damage after antiseptic treatment.International orthopaedics · 2014Article
- Effects of indigo carmine on human chondrocytes in vitro.The open orthopaedics journal · 2013Article
- Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes.International orthopaedics · 2013Article
- [Joint infections. Known facts and new trends].Der Unfallchirurg · 2012Article
- Efficacy of taurolidine against periodontopathic species--an in vitro study.Clinical oral investigations · 2012Article
- The role of hydrogen peroxide in hip arthroplasty: A narrative review.Journal of perioperative practiceReview
- Tranexamic acid is toxic on human chondrocytes,Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In septic joint surgery, the most frequently used antiseptics are polyhexanide, hydrogen peroxide and taurolidine. The aim of this study was to examine the effects of these antiseptics on viability of human chondrocytes. Our hypothesis was that antiseptics and supplemental irrigation with sodium chloride lavage are less toxic on human chondrocytes than treatment with antiseptics only. Primary human chondrocytes were isolated and cultured from six donated human knee joints. Polyhexanide, hydrogen peroxide or taurolidine were added to the cultures. Toxicity analysis was performed by visualisation of cell structure using light microscopy and LDH activity. The determination of vital cells and total cell numbers of chondrocytes treated with antiseptics partly followed by irrigation with sodium chloride solution was performed by using Casy Cell-Counter. Light microscopic data revealed a defect in cell structure after addition of antiseptics. We showed a significant increase of LDH enzyme activity after the treatment with polyhexanide or taurolidine. After treatment with antiseptics followed by sodium chloride solution a significant increase of vital and total cell numbers resulted in comparison with the chondrocytes that were only treated with antiseptics. The data show that treatment with polyhexanid, hydrogen peroxide or taurolidine induces cell death of human chondroctes in vitro. The application of sodium chloride solution after the treatment with polyhexanide and hydrogen peroxide possibly has a protective effect on chondrocyte viability.
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