ArticlePediatric nephrology (Berlin, Germany)2011
Long-term risk of chronic kidney disease in unilateral multicystic dysplastic kidney.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 87 citations in OpenAlex.
- Clinical course of unilateral multicystic dysplastic kidney and contralateral kidney in Korean children: a single-center, retrospective study.Childhood kidney diseases · 2026Article
- Paediatric multicystic dysplastic kidney disease in Cape Town, South Africa.BMC nephrology · 2025Article
- Congenital solitary functioning kidney: evaluations to do which, when, and how.Childhood kidney diseases · 2024Review
- Early predictive factors for progression to kidney failure in infants with severe congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD).Journal of clinical medicine · 2022Review
- Associated Anomalies and Complications of Multicystic Dysplastic Kidney.Pediatric reports · 2022Article
- Management of the congenital solitary kidney: consensus recommendations of the Italian Society of Pediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2022Review
- Outcomes of solitary functioning kidneys-renal agenesis is different than multicystic dysplastic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Retrospective evaluation of the pediatric multicystic dysplastic kidney patients: experience of two centers from southeastern TurkeyTurkish journal of medical sciences · 2021Article
- Pathophysiological clinical features of an infant with hypertension secondary to multicystic dysplastic kidney: a case report.BMC nephrology · 2021Article
- Reverse Phenotyping Maternal Cystic Kidney Disease by Diagnosis in a Newborn: Case Report and Literature Review on Neonatal Cystic Kidney Diseases.Acta medica Lituanic · 2021Article
- Developmental pathology of congenital kidney and urinary tract anomalies.Clinical kidney journal · 2019Article
- Correlation between hypertrophy and risk of hypertension in congenital solitary functioning kidney.Pediatric surgery international · 2019Article
- Whole-exome sequencing in the molecular diagnosis of individuals with congenital anomalies of the kidney and urinary tract and identification of a new causative gene.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- The impact of small kidneys.Pediatric nephrology (Berlin, Germany) · 2015Article
- Diagnostic Accuracy of the Quantitative C-Reactive Protein, Erythrocyte Sedimentation Rate and White Blood Cell Count in Urinary Tract Infections among Infants and Children.The Malaysian journal of medical sciences : MJMS · 2013Article
- Cowden disease and multicystic dysplastic kidney: increased risk of renal cancer?Clinical kidney journal · 2012Article
- Unilateral multicystic dysplastic kidney: does initial size matter?Pediatric nephrology (Berlin, Germany) · 2012Article
- 99mTc-MAG3 scintigraphy for the longitudinal follow-up of kidney function in a mouse model of renal ischemia-reperfusion injury.EJNMMI research · 2012Article
- Reducing selection bias in case-control studies from rare disease registries.Orphanet journal of rare diseases · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical spectrum of renal dysplasia includes the non-functioning multicystic dysplastic kidney (MCDK). We report our experience of the outcome of unilateral MCDK and its contralateral kidney in 101 children with the diagnosis of MCDK from 1985 to 2009. Data collected included urine protein/creatinine ratio, estimated GFR (eGFR), blood pressure, surgical intervention, renal length and abnormalities of the contralateral kidney, and the involution rate. There was a predominance of left-sided MCDK. Diagnosis was made prenatally in 86.7%. Contralateral abnormalities included vesicoureteral reflux (16.8%), UPJ obstruction (4.1%), and megaureter (2.4%). Complete involution of MCDK occurred within 5 years in 60%. Compensatory hypertrophy of the contralateral kidney to >97% occurred in 74.1%. Nephrectomy was performed in 19.8%. There was an increased risk of chronic kidney disease (CKD) stage ≥ 2, and hypertension in those with contralateral abnormalities (p<0.0001; p<0.001 respectively). In those without contralateral abnormalities, hyperfiltration with mean eGFR of 149 ± 13 ml/min/1.73 m(2) was seen in 32% and proteinuria in 9.8%. There was a significantly inverse relationship between proteinuria and eGFR (p<0.0001). In conclusion, children with contralateral abnormalities are at risk for developing decreased kidney function, whereas a substantial number of patients with no obvious contralateral abnormalities have markers of renal injury. Therefore, systematic follow-up of all patients is recommended.
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