SynthesisJournal of cancer research and clinical oncology2011
Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.
Synthesis in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A comprehensive evaluation for polymorphisms inBioscience reports · 2018Pooled it
- Association betweenDisease markers · 2018Pooled it
- Association between MDM2 SNP309, p53 Arg72Pro, and hepatocellular carcinoma risk: A MOOSE-compliant meta-analysis.Medicine · 2017Pooled it
- Significant association between XRCC3 C241T polymorphism and increased risk of hepatocellular carcinoma: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- HFE gene C282Y variant is associated with colorectal cancer in Caucasians: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans.The Journal of clinical investigation · 2013Trial
- Expression of PDZ domain-containing proteins is correlated with prognosis and immune infiltration in hepatocellular carcinoma.Journal of gastrointestinal oncology · 2025Article
- The Emerging Roles of Long Non-Coding RNAs in Intellectual Disability and Related Neurodevelopmental Disorders.International journal of molecular sciences · 2022Review
- Unique situation of hepatocellular carcinoma in Egypt: A review of epidemiology and control measures.World journal of gastrointestinal oncology · 2021Review
- Epidemiology of Hepatocellular Carcinoma.Hepatology (Baltimore, Md.) · 2021Review
- Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study.Cancer medicine · 2019Article
- Association of lncRNAInternational journal of environmental research and public health · 2019Article
- Association of lncRNAGenes · 2019Article
- Impact of HFE variants and sex in lung cancer.PloS one · 2019Article
- Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population.Frontiers in genetics · 2019Article
- GTSF1 gene may serve as a novel potential diagnostic biomarker for liver cancer.Oncology letters · 2018Article
- Association of melatonin membrane receptor 1A/1B gene polymorphisms with the occurrence and metastasis of hepatocellular carcinoma.Oncotarget · 2017Article
- Genetic biomarkers for hepatocellular cancer risk in a caucasian population.World journal of gastroenterology · 2017Article
- Analysis of single nucleotide variants of HFE gene and association to survival in The Cancer Genome Atlas GBM data.PloS one · 2017Article
- Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFor decades of years, hundreds of candidate gene-based association studies explored the relationship between single nucleotide polymorphisms (SNPs) and hepatocellular carcinoma (HCC). There was no systematic review summarized the results of these association studies of candidate SNPs and HCC to date. In order to summarize the results of the association studies, we conducted a concise systematic review.
methodsBy searching Pubmed database before October 2010, we reviewed all the association studies about candidate SNPs and HCC. If the eligible study number on a given SNP was more than three, we conducted a meta-analysis. We reported here only the overall positive-association results with statistical significance and evaluated the reliability of the associations by using false-positive report probability (FPRP) analysis and the Venice guidelines on genetic epidemiology studies.
resultsSix SNPs of five genes (rs1800562 of HFE, rs17868323 and rs11692021 of UGT1A7, rs2279744 of MDM2, rs1143627 of IL-1B, and rs4880 of MnSOD) showed overall significant associations with HCC. The eligible number of the studies varied from three to nine. Two SNPs (rs1800562 of HFE and rs2279744 of MDM2) passed the FPRP threshold (FPRP < 0.20). According to the Venice guidelines, the associations between the two SNPs (rs1800562 and rs2279744) and HCC were of moderate evidence.
conclusionsTwo SNPs (rs1800562 of HFE and rs2279744 of MDM2) were associated with HCC with moderate epidemiological evidence and deserve further study and additional biological and clinical assessment.
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