ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2011
Amelioration of selenite toxicity and cataractogenesis in cultured rat lenses by Vitex negundo.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 18 citations in OpenAlex.
- Pharmacological Strategies for Cataract Management: From Molecular Targets to Clinical Translation.International journal of molecular sciences · 2025Review
- Effect of Moringa oleifera stem extract on hydrogen peroxide-induced opacity of cultured mouse lens.BMC complementary and alternative medicine · 2019Article
- Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.Interdisciplinary toxicology · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent evidence suggests that oxidative stress plays a significant role in the development of cataract. The present study sought to evaluate the efficacy of flavonoid fraction of Vitex negundo (FVN) in preventing the toxicity induced by sodium selenite in vitro culture condition.
methodsEnucleated rat lenses were maintained in organ culture containing DMEM medium alone (G I), supplemented with 0.1mM sodium selenite (G II), sodium selenite + 20 μg/ml quercetin (G III) and sodium selenite + 50 μg/ml FVN (G IV). Treatment was from the second to fifth day, while selenite administration was done on the third day. After the experimental period, lenses were taken out and the activities of superoxide dismutase (SOD), catalase, Ca(2+) ATPase, levels of reduced glutathione (GSH), calcium, reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), and sulfhydryl content were studied.
resultsMorphological examination revealed dense vacuolization and loss of cortical transparency in G II compared to control and treated group. The mean activities of the enzymes SOD, catalase and Ca(2+) ATPase, levels of GSH and sulfhydryl content were significantly reduced in lenses of G II compared to control. In addition, the mean levels of ROS, calcium and TBARS were elevated in G II compared to control. However, these changes were modulated by FVN treatment to further strengthen its protective role over selenite cataract.
conclusionThese results suggest that FVN treatment prevented selenite toxicity and cataractogenesis by maintaining antioxidant status, calcium homeostasis, protecting sulfhydryl group, and decreasing oxidative stress in lens, which may be due to its protective effects.
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