ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05423470 (Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Acute exercise increases resistance to oxidative stress in young but not older adults.Age (Dordrecht, Netherlands) · 2014Trial
- Trial
- The inter-arm diastolic blood pressure difference induced by one arm ischemia: a new approach to assess vascular endothelia function.PloS one · 2014Trial
- The conducted vasomotor response and the principles of electrical communication in resistance arteries.Physiological reviews · 2024Review
- Acute heat exposure protects against endothelial ischemia-reperfusion injury in aged humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Short-term exercise-induced protection of cardiovascular function and health: why and how fast does the heart benefit from exercise?The Journal of physiology · 2022Review
- Effect of endoplasmic reticulum stress on endothelial ischemia-reperfusion injury in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Aging women and their endothelium: probing the relative role of estrogen on vasodilator function.American journal of physiology. Heart and circulatory physiology · 2019Review
- Ischaemic and hypoxic conditioning: potential for protection of vital organs.Experimental physiology · 2019Review
- 12-Week Exercise Training, Independent of the Type of Exercise, Attenuates Endothelial Ischaemia-Reperfusion Injury in Heart Failure Patients.Frontiers in physiology · 2019Article
- Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury.Nutrition and metabolic insights · 2016Article
- Hypoxia-inducible factor 1 alpha contributes to pulmonary vascular dysfunction in lung ischemia-reperfusion injury.International journal of clinical and experimental pathology · 2014Article
- Article
- Article
- Vascular health in the ageing athlete.Experimental physiology · 2012Article
- Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions.Microcirculation (New York, N.Y. : 1994) · 2012Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Advancing age is a major risk factor for coronary artery disease. Endothelial dysfunction accompanied by increased oxidative stress and inflammation with aging may predispose older arteries to greater ischemia-reperfusion (I/R) injury. Because coronary artery ischemia cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I/R injury have not been determined in humans. Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery flow-mediated dilation (FMD), was measured before and after 20 min of continuous forearm occlusion in young sedentary (n = 10, 24 ± 2 yr) and middle-aged (n = 9, 48 ± 2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I/R injury. Young (n = 9, 25 ± 1 yr) and middle-aged endurance-trained (n = 9, 50 ± 2 yr) adults were also studied to determine whether habitual exercise provides protection from I/R injury. Fifteen minutes after ischemic injury, FMD decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. FMD returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained depressed in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and inflammation were not related to FMD. In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I/R injury in humans. Habitual endurance exercise may provide partial protection to the endothelium against this form of I/R injury with advancing age.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.