ArticleMolecular endocrinology (Baltimore, Md.)2011
Role of reactive oxygen species in injury-induced insulin resistance.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Regulation of Keap1-Nrf2 signaling in health and diseases.Molecular biology reports · 2024Review
- Adipocyte lipolysis drives acute stress-induced insulin resistance.Scientific reports · 2020Article
- Data-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Article
- Regioisomer-independent quantification of fatty acid oxidation products by HPLC-ESI-MS/MS analysis of sodium adducts.Scientific reports · 2019Article
- Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction.Antioxidants (Basel, Switzerland) · 2019Article
- Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas.International journal of molecular sciences · 2017Article
- The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome.Reviews in endocrine & metabolic disorders · 2015Review
- Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock.The journal of trauma and acute care surgery · 2014Article
- Regulation of hepatic insulin receptor activity following injury.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock.Shock (Augusta, Ga.) · 2014Article
- Hepatic growth hormone resistance after acute injury.Endocrinology · 2013Article
- Stress-induced hyperglycemia is a valuable biomarker in febrile neutropenia.Revista brasileira de hematologia e hemoterapia · 2013Article
- Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function.Lipids in health and disease · 2012Review
- Role of tissue macrophages in the development of critical illness diabetes.Shock (Augusta, Ga.) · 2012Article
- Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Acute insulin resistance is common after injury, infection, and critical illness. To investigate the role of reactive oxygen species (ROS) in critical illness diabetes, we measured hepatic ROS, which rapidly increased in mouse liver. Overexpression of superoxide dismutase 2, which decreased mitochondrial ROS levels, protected mice from the development of acute hepatic insulin resistance. Insulin-induced intracellular signaling was dramatically decreased, and cellular stress signaling was rapidly increased after injury, resulting in the hyperglycemia of critical illness diabetes. Insulin-induced intracellular signaling, activation of stress (c-Jun N-terminal kinase) signaling, and glucose metabolism were all normalized by superoxide dismutase 2 overexpression or by pretreatment with antioxidants. Thus, ROS play an important role in the development of acute hepatic insulin resistance and activation of stress signaling after injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.