ArticleThe Journal of clinical endocrinology and metabolism2011
Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Lipid metabolism in the adrenal gland.Frontiers in endocrinology · 2025Review
- A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma.Frontiers in endocrinology · 2023Article
- Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies.Endocrine reviews · 2022Article
- RNA-Sequencing Analysis of Gene-Expression Profiles in the Dorsal Gland ofLife (Basel, Switzerland) · 2022Article
- Steroidogenic Factor 1 Regulation of the Hypothalamic-Pituitary-Ovarian Axis of Adult Female Mice.Endocrinology · 2022Article
- Robust differentiation of human enteroendocrine cells from intestinal stem cells.Nature communications · 2022Article
- Screening and Identification of Differential Ovarian Proteins before and after Induced Ovulation via Seminal Plasma in Bactrian Camels.Animals : an open access journal from MDPI · 2021Article
- Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer.Cancers · 2020Article
- Article
- SOAT1 methylation is associated with coronary heart disease.Lipids in health and disease · 2019Article
- Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism.International journal of molecular sciences · 2018Review
- Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess.European journal of endocrinology · 2018Article
- POD-1/Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.Best practice & research. Clinical endocrinology & metabolism · 2015Review
- Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators.The Journal of steroid biochemistry and molecular biology · 2015Review
- Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.Molecular and cellular endocrinology · 2015Review
- Integrative analysis of SF-1 transcription factor dosage impact on genome-wide binding and gene expression regulation.Nucleic acids research · 2013Article
- Steroidogenic factor-1 and human disease.Seminars in reproductive medicine · 2012Review
- Article
- NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms.Reproductive medicine and biologyReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
contextSteroidogenic factor-1 (SF-1, NR5A1, Ad4BP) is a master regulator of adrenal development and steroidogenesis. Defects in several known targets of SF-1 can cause adrenal disorders in humans.
objectiveWe aimed to identify novel targets of SF-1 in the human adrenal. These factors could be important regulators of adrenal development and steroidogenesis and potential candidates for adrenal dysfunction.
designA gene discovery strategy was developed based on bidirectional manipulation of SF-1. Overexpression or knockdown of SF-1 in NCI-H295R human adrenocortical cells was used to identify a subset of positively-regulated SF-1 targets.
resultsThis approach identified well-established SF-1 target genes (STAR, CYP11A) and several novel genes (VSNL1, ZIM2, PEG3, SOAT1, and MTSS1). Given its role in cholesterol metabolism, sterol O-acyltransferase 1 (SOAT1, previously referred to as acyl-Coenzyme A:cholesterol acyltransferase 1, ACAT) was studied further and found to be expressed in the developing human fetal adrenal cortex. We hypothesized that impaired SOAT1 activity could result in adrenal insufficiency through reduced cholesteryl ester reserves or through toxic destruction of the adrenal cells during development. Therefore, mutational analysis of SOAT1 in a cohort of 43 patients with unexplained adrenal insufficiency was performed but failed to reveal significant coding sequence changes.
conclusionsOur reverse discovery approach led to the identification of novel SF-1 targets and defined SOAT1 as an important factor in human adrenal steroidogenesis. SF-1-dependent up-regulation of SOAT1 may be important for maintaining readily-releasable cholesterol reserves needed for active steroidogenesis and during episodes of recurrent stress.
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