ArticleThe Journal of biological chemistry2011
Impact of the metabolic activity of Streptococcus thermophilus on the colon epithelium of gnotobiotic rats.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 46 citations in OpenAlex.
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- Characterization of Mucus-Related Properties ofFrontiers in physiology · 2018Article
- Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective.Frontiers in microbiology · 2018Review
- Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome.Frontiers in physiology · 2017Article
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- Early colonizing Escherichia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state.The ISME journal · 2015Article
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- Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome.PloS one · 2013Article
- Behavior of lactobacilli isolated from fermented slurry (ben-saalga) in gnotobiotic rats.PloS one · 2013Article
- Article
- Carbohydrate metabolism is essential for the colonization of Streptococcus thermophilus in the digestive tract of gnotobiotic rats.PloS one · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thermophilic lactic acid bacterium Streptococcus thermophilus is widely and traditionally used in the dairy industry. Despite the vast level of consumption of S. thermophilus through yogurt or probiotic functional food, very few data are available about its physiology in the gastrointestinal tract (GIT). The objective of the present work was to explore both the metabolic activity and host response of S. thermophilus in vivo. Our study profiles the protein expression of S. thermophilus after its adaptation to the GIT of gnotobiotic rats and describes the impact of S. thermophilus colonization on the colonic epithelium. S. thermophilus colonized progressively the GIT of germ-free rats to reach a stable population in 30 days (10(8) cfu/g of feces). This progressive colonization suggested that S. thermophilus undergoes an adaptation process within GIT. Indeed, we showed that the main response of S. thermophilus in the rat's GIT was the massive induction of the glycolysis pathway, leading to formation of lactate in the cecum. At the level of the colonic epithelium, the abundance of monocarboxylic acid transporter mRNAs (SLC16A1 and SLC5A8) and a protein involved in the cell cycle arrest (p27(kip1)) increased in the presence of S. thermophilus compared with germ-free rats. Based on different mono-associated rats harboring two different strains of S. thermophilus (LMD-9 or LMG18311) or weak lactate-producing commensal bacteria (Bacteroides thetaiotaomicron and Ruminococcus gnavus), we propose that lactate could be a signal produced by S. thermophilus and modulating the colon epithelium.
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