ArticleEndocrinology2011
Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Investigating autoimmunity in the etiology of premature ovarian insufficiency in a mouse model.Journal of reproductive immunology · 2026Article
- Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule.EMBO molecular medicine · 2026Article
- What do women and rhinos have in common?F&S reports · 2025Article
- Phosphomannomutase 2-congenital disorder of glycosylation: exploring the role of N-glycosylation on the endocrine axes.Frontiers in endocrinology · 2025Review
- Decreased glutathione synthesis in granulosa cells, but not oocytes, of growing follicles decreases fertility in mice†.Biology of reproduction · 2024Article
- Rescue of follicle development after oocyte-induced ovary dysfunction and infertility in a model of POI.Frontiers in cell and developmental biology · 2023Article
- Rapid ovarian transcript changes during the onset of premature ovarian insufficiency.Reproduction & fertility · 2022Article
- Mouse Cre drivers: tools for studying disorders of the human female neuroendocrine-reproductive axis†.Biology of reproduction · 2022Review
- Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure.Human reproduction (Oxford, England) · 2022Article
- Roles for Golgi Glycans in Oogenesis and Spermatogenesis.Frontiers in cell and developmental biology · 2019Review
- Molecular Cloning of theAnimals : an open access journal from MDPI · 2018Article
- Analysis of in vitro follicle development during the onset of premature ovarian insufficiency in a mouse model.Reproduction, fertility, and development · 2017Article
- Dysregulation of follicle development in a mouse model of premature ovarian insufficiency.Reproduction (Cambridge, England) · 2016Article
- Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure.Endocrinology · 2014Article
- Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion.Endocrinology · 2014Article
- The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary.PLoS genetics · 2013Article
- Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.Reproduction (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Premature ovarian failure (POF) affects up to 1.4% of women under the age of 40 yr and less than 30% of cases have a known cause. Here we describe a new mouse model of POF resulting from oocyte-specific ablation of core 1-derived (mucin) O-glycans and complex and hybrid N-glycans. Females carrying floxed alleles of both the C1galt1 (T-syn) and Mgat1 glycosyltransferase genes and a ZP3Cre transgene, generate oocytes lacking complex O- and N-glycans following oocyte-specific deletion at the primary follicle stage. We previously showed that few double-mutant females are fertile, and those produce only a single small litter. Here we show that ovarian function declined rapidly in double-mutant females with less than 1% ovulating at 11 wk of age after superovulation with exogenous gonadotropins. Ovary weight was significantly decreased in double-mutant females by 3 months of age, consistent with a decrease in the number of developing follicles. FSH levels in double-mutant females were elevated at 3 months of age, and testosterone and inhibin A were decreased, showing that the loss of complex N- and O-glycans from oocyte glycoproteins affected hypothalamic-pituitary-gonadal feedback loops. The absence of developing follicles, ovary dysfunction, reduced testosterone and inhibin A, and elevated FSH in double-mutant females lacking C1galt1 and Mgat1 in oocytes represents a new mouse model for the study of follicular POF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.