ArticleTrends in immunology2011
Seeking common pathophysiology in asthma, atopy and sinusitis.
Article in Trends in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.Immunity · 2021Article
- Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi.Frontiers in immunology · 2019Review
- Fungi in Mucoobstructive Airway Diseases.Annals of the American Thoracic Society · 2018Review
- Innate and adaptive immune responses to fungi in the airway.The Journal of allergy and clinical immunology · 2018Review
- C-Type Lectin Receptors in Asthma.Frontiers in immunology · 2018Review
- Allergic Aspergillus Rhinosinusitis.Journal of fungi (Basel, Switzerland) · 2016Review
- A Review of Classification Schemes for Chronic Rhinosinusitis with Nasal Polyposis Endotypes.Laryngoscope investigative otolaryngology · 2016Review
- ILC2s and fungal allergy.Allergology international : official journal of the Japanese Society of Allergology · 2015Review
- B cells play key roles in th2-type airway immune responses in mice exposed to natural airborne allergens.PloS one · 2015Article
- IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Airway surface mycosis in chronic TH2-associated airway disease.The Journal of allergy and clinical immunology · 2014Article
- Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- High rates of detection of respiratory viruses in the nasal washes and mucosae of patients with chronic rhinosinusitis.Journal of clinical microbiology · 2013Article
- Immunotherapy in allergic fungal sinusitis: The controversy continues. A recent review of literature.Allergy & rhinology (Providence, R.I.) · 2013Article
- Necessary and sufficient role for T helper cells to prevent fungal dissemination in allergic lung disease.Infection and immunity · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Asthma and chronic sinusitis are inexplicably common airway diseases that are linked to atopy and allergic inflammation. T helper type 2 (Th2) cells and the associated cytokines are believed to play crucial pathogenic roles in asthma, but the environmental factors that instigate allergic airway disease remain poorly understood. Environmental proteinases are highly allergenic and are candidate inducers of airway Th2 responses. Determining the proteinases and their sources that are relevant to airway disease, however, remains challenging. In this Opinion, we summarize the evidence that implicates fungi as both a relevant source of allergenic proteinases and a potential cause of asthma, atopy and chronic sinusitis through airway infection. Clarification of the extrinsic causes of these processes will markedly improve diagnosis, prognosis and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.