Evidence map›Paper›PMID 21239093›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2011

Role of nutritional status and inflammation in higher survival of African American and Hispanic hemodialysis patients.

Elani Streja, Csaba P Kovesdy, Miklos Z Molnar, Keith C Norris, Sander Greenland, Allen R Nissenson, Joel D Kopple, Kamyar Kalantar-Zadeh

Registry-linked trialOpen access · greenAbstract readComparative Study
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01415570 (Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease), which is not on this map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01415570 unknown statusnot on this map

Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease (CKD) - A Prospective Data Collection Study

TypeobservationalSponsorLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterRan2011 to 2016Enrolled1,050ConditionsChronic Kidney Disease (CKD), End-Stage Renal Disease (ESRD)
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Association of serum globulin with all-cause mortality in incident hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
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  13. Transition of care from pre-dialysis prelude to renal replacement therapy: the blueprints of emerging research in advanced chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017
    Review
  14. Longitudinal trends in serum ferritin levels and associated factors in a national incident hemodialysis cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017
    Article
  15. Article
  16. Article
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  19. Social Determinants of Racial Disparities in CKD.Journal of the American Society of Nephrology : JASN · 2016
    Review
  20. Examining the robustness of the obesity paradox in maintenance hemodialysis patients: a marginal structural model analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Elani StrejaHarold Simmons Center for Chronic Disease Research and Epidemiology, Torrance, CA, USA.
Csaba P Kovesdy
Miklos Z Molnar
Keith C Norris
Sander Greenland
Allen R Nissenson
Joel D Kopple
Kamyar Kalantar-Zadeh
The Lundquist Institute · USCharles R. Drew University of Medicine and Science · USSalem VA Medical Center · USSemmelweis University · HUUniversity of California, Los Angeles · US

Funding

Sustaining Faculty Development & Community EngagementS21MD000103 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CARLISLE, DAVID M · 2001 to 2015
$73.9M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI MILBURN, NORWEETA GERMAINE, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
VITAMIN D STIMULATES CARDIAC DIFFERENTIATIONU54RR026138 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI HSIA, STANLEY · 2009 to 2011
$14.0M
Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseR01DK078106 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALANTAR-ZADEH, KAMYAR · 2007 to 2011
$1.1M
Nutritional/Inflammatory Evaluation of Dialysis PatientsK23DK061162 · NIDDK · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI KALANTAR-ZADEH, KAMYAR · 2001 to 2005
$797k
NCRR NIH HHS RR026138NIDDK NIH HHS K23 DK061162NIDDK NIH HHS R01 DK078106NIMHD NIH HHS MD000103NIMHD NIH HHS MD00182
6 · The paper itself

Abstract

backgroundObservational studies indicate greater survival in African American and Hispanic maintenance hemodialysis patients compared with their non-Hispanic white counterparts, although African Americans have shorter life expectancy than whites in the general population. We hypothesized that this apparent survival advantage is due to a more favorable nutritional/inflammatory profile in minority hemodialysis patients. STUDY

designWe examined the association between race/ethnicity and 5-year survival before and after adjustment for case-mix and surrogates of the malnutrition-inflammation complex syndrome (MICS) using Cox regression with or without matched sampling in a large cohort of adult hemodialysis patients. SETTING &

participants124,029 adult hemodialysis patients, including 16% Hispanics, 49% non-Hispanic whites, and 35% African Americans. PREDICTORS: Race/ethnicity before and after adjustment for MICS, including values for body mass index, serum albumin, total iron-binding capacity, ferritin, creatinine, phosphorus, calcium, bicarbonate, white blood cell count, lymphocyte percentage, hemoglobin, and protein intake. OUTCOMES: 5-year (July 2001 to June 2006) survival.

resultsIn dialysis patients, blacks and Hispanics had lower mortality overall than non-Hispanic whites after traditional case-mix adjustment. However, after additional control for MICS, Hispanics had mortality similar to non-Hispanic whites, and African Americans had even higher mortality. Unadjusted, case-mix-, and MICS-adjusted HRs for African Americans versus whites were 0.68 (95% CI, 0.66-0.69), 0.89 (95% CI, 0.86-0.91), and 1.06 (95% CI, 1.03-1.09) in the unmatched cohort and, 0.95 (95% CI, 0.90-0.99), 0.89 (95% CI, 0.84-0.94), and 1.16 (95% CI, 1.07-1.26) in the matched cohort, and for Hispanics versus whites, 0.66 (95% CI, 0.64-0.69), 0.84 (95% CI, 0.81-0.87), and 0.97 (95% CI, 0.94-1.00) in the unmatched cohort and 0.89 (95% CI, 0.84-0.95), 0.88 (95% CI, 0.83-0.95), and 0.98 (95% CI, 0.91-1.06) in the matched cohort, respectively. LIMITATIONS: Adjustment cannot be made for unmeasured confounders.

conclusionsSurvival advantages of African American and Hispanic hemodialysis patients may be related to differences in nutritional and inflammatory status. Further studies are required to explore these differences.

Indexed as

Black or African AmericanHispanic or LatinoNutritional StatusAdolescentAdultAgedFemaleFollow-Up StudiesHumansInflammationKidney Failure, ChronicMaleMiddle AgedRenal DialysisRetrospective StudiesTime Factors

Identifiers

PMID21239093
PMCPMC3081903
OpenAlexW2038327657

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.