Evidence map›Paper›PMID 21239051›Full record

ArticleLancet (London, England)2011

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.

Muredach P Reilly, Mingyao Li, Jing He, Jane F Ferguson, Ioannis M Stylianou, Nehal N Mehta, Mary Susan Burnett, Joseph M Devaney, Christopher W Knouff, John R Thompson and 24 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 21 pooled it
33.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 21 syntheses or guidelines pooled it, 534 citations in OpenAlex.

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  14. Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.Journal of the American Society of Nephrology : JASN · 2018
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204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors at 19 institutions in 5 countries.

Muredach P ReillyCardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA. muredach@mail.med.upenn.edu
Mingyao Li
Jing He
Jane F Ferguson
Ioannis M Stylianou
Nehal N Mehta
Mary Susan Burnett
Joseph M Devaney
Christopher W Knouff
John R Thompson
Benjamin D Horne
Alexandre F R Stewart
Themistocles L Assimes
Philipp S Wild
Hooman Allayee
Patrick Linsel Nitschke
Riyaz S Patel
Myocardial Infarction Genetics Consortium
Wellcome Trust Case Control Consortium
Nicola Martinelli
Domenico Girelli
Arshed A Quyyumi
Jeffrey L Anderson
Jeanette Erdmann
Alistair S Hall
Heribert Schunkert
Thomas Quertermous
Stefan Blankenberg
Stanley L Hazen
Robert Roberts
Sekar Kathiresan
Nilesh J Samani
Stephen E Epstein
Daniel J Rader
Cardiovascular Institute of the South · USUniversity of Lübeck · DEUniversity of Pennsylvania · USEmory University · USJohannes Gutenberg University Mainz · DEMedStar Washington Hospital Center · USStanford University · USUniversity of Leicester · GBUniversity of Ottawa · CAUniversity of Verona · ITCenter for Human Genetics · USCleveland Clinic · USGlaxoSmithKline (United States) · USIntermountain Medical Center · USMedStar Health · USTranslational Therapeutics (United States) · USUniversity of Leeds · GBUniversity of Southern California · USUniversity of Utah · US

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2004 to 2019
$27.3M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
AN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORKU54RR020278 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2004 to 2008
$14.4M
Regression of Atherosclerosis CoreP01HL098055 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FISHER, EDWARD A · 2010 to 2014
$12.1M
Institutional Clinical and Translational Science AwardKL2RR024132 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$5.1M
A Genome-wide Association Study for Early-Onset Myocardial InfarctionR01HL087676 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ALTSHULER, DAVID · 2007 to 2009
$4.7M
Whole Genome Association for Early Coronary Artery Disease and Related PhenotypesR01HL087647 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2006 to 2008
$4.6M
Genetics of atherosclerosis in renal diseaseR01DK071224 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REILLY, MUREDACH P · 2006 to 2010
$2.9M
Risk Burden of Lipoprotein Metabolic Gene HaplotypesR01HL071878 · NHLBI · IHC HEALTH SERVICES, INC. · PI ANDERSON, JEFFREY LANCE · 2004 to 2007
$2.3M
Human translational studies of CXCL12: a novel GWAS atherosclerosis locusK23HL097151 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEHTA, NEHAL N · 2009 to 2011
$411k
British Heart FoundationChief Scientist Office CZB/4/540CIHR MOP172605CIHR MOP77682CIHR MOP-82810Medical Research Council G0600329Medical Research Council G0800675Medical Research Council G0800759NCATS NIH HHS UL1 TR000454NCRR NIH HHS KL2 RR024132NCRR NIH HHS U54 RR020278NHLBI NIH HHS 1P01 HL098055-01NHLBI NIH HHS HL087647NHLBI NIH HHS K23 HL097151NHLBI NIH HHS P01 HL076491NHLBI NIH HHS P01 HL076491-06NHLBI NIH HHS P01 HL098055NHLBI NIH HHS R01- HL071878NHLBI NIH HHS R01 HL087676NIDDK NIH HHS R01 DK071224Wellcome Trust 090532Wellcome Trust 091157
6 · The paper itself

Abstract

backgroundWe tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis.

methodsWe did two genome-wide association studies (GWAS) with coronary angiographic phenotyping in participants of European ancestry. To identify loci that predispose to angiographic coronary artery disease (CAD), we compared individuals who had this disorder (n=12,393) with those who did not (controls, n=7383). To identify loci that predispose to myocardial infarction, we compared patients who had angiographic CAD and myocardial infarction (n=5783) with those who had angiographic CAD but no myocardial infarction (n=3644).

findingsIn the comparison of patients with angiographic CAD versus controls, we identified a novel locus, ADAMTS7 (p=4·98×10(-13)). In the comparison of patients with angiographic CAD who had myocardial infarction versus those with angiographic CAD but no myocardial infarction, we identified a novel association at the ABO locus (p=7·62×10(-9)). The ABO association was attributable to the glycotransferase-deficient enzyme that encodes the ABO blood group O phenotype previously proposed to protect against myocardial infarction.

interpretationOur findings indicate that specific genetic predispositions promote the development of coronary atherosclerosis whereas others lead to myocardial infarction in the presence of coronary atherosclerosis. The relation to specific CAD phenotypes might modify how novel loci are applied in personalised risk assessment and used in the development of novel therapies for CAD.

fundingThe PennCath and MedStar studies were supported by the Cardiovascular Institute of the University of Pennsylvania, by the MedStar Health Research Institute at Washington Hospital Center and by a research grant from GlaxoSmithKline. The funding and support for the other cohorts contributing to the paper are described in the webappendix.

Indexed as

Genetic LociGenome-Wide Association StudyPolymorphism, Single NucleotideABO Blood-Group SystemADAM ProteinsADAMTS7 ProteinAdultAgedCoronary AngiographyCoronary Artery DiseaseFemaleGene FrequencyGenetic Predisposition to DiseaseHumansLinkage DisequilibriumMaleABO Blood-Group SystemADAM ProteinsADAMTS7 ProteinADAMTS7 protein, human

Identifiers

PMID21239051
PMCPMC3297116
OpenAlexW2169936655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.