ArticleVirology2011
Multiple HIV-1 infections with evidence of recombination in heterosexual partnerships in a low risk Rural Clinical Cohort in Uganda.
Article in Virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The HIV Genomic Incidence Assay Meets False Recency Rate and Mean Duration of Recency Infection Performance Standards.Scientific reports · 2017Pooled it
- Functionally-informed fine-mapping identifies genetic variants linking increased CHD1L expression and HIV restriction in monocytes.Scientific reports · 2025Article
- Article
- Molecular Epidemiology of HIV-1 in African Countries: A Comprehensive Overview.Pathogens (Basel, Switzerland) · 2020Review
- Pervasive and non-random recombination in near full-length HIV genomes from Uganda.Virus evolution · 2020Article
- Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection.The Journal of infectious diseases · 2018Article
- Article
- Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide.Molecular therapy. Nucleic acids · 2017Article
- Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles.AIDS (London, England) · 2017Article
- HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China.Scientific reports · 2017Article
- Intergenic incompatibilities reduce fitness in hybrids of extremely closely related bacteriophages.PeerJ · 2015Article
- Article
- Article
- The adaptive potential of hybridization demonstrated with bacteriophages.Journal of molecular evolution · 2013Article
- Short communication: HIV type 1 transmitted drug resistance and evidence of transmission clusters among recently infected antiretroviral-naive individuals from Ugandan fishing communities of Lake Victoria.AIDS research and human retroviruses · 2013Article
- Effect of HIV-1 subtypes on disease progression in rural Uganda: a prospective clinical cohort study.PloS one · 2013Article
- Recent advances in research of HIV infection: implications of viral and host genetics on treatment and prevention.Public health genomics · 2013Review
- Frequency of subtype B and F1 dual infection in HIV-1 positive, Brazilian men who have sex with men.Virology journal · 2012Article
- Enrichment of HIV-1 subtype AD recombinants in a Ugandan cohort of severely septic patients.PloS one · 2012Article
- HIV-1 subtypes and recombinants in Northern Tanzania: distribution of viral quasispecies.PloS one · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
We report on the frequency of multiple infections, generation of recombinants and consequences on disease progression in 35 HIV-1 infected individuals from 7 monogamous and 6 polygamous partnerships within a Rural Clinical Cohort in Uganda. The env-C2V3, gag-p24 and pol-IN genes were sequenced. Single genome amplified half genome sequences were used to map recombination breakpoints. Three participants were dually infected with subtypes A and D, one case with subtype A and A/D recombinant and the fifth with 2 phylogenetically distinct A/D recombinants. Occurrence of A/D recombination was observed in two multiple infected individuals. Rate of late stage WHO events using Cox regression was 3 times greater amongst multiple infected compared to singly infected individuals (hazard ratio 3.35; 95% CI 1.09, 10.3; p=0.049). We have shown that polygamous relationships involving subtype discordant partnerships was a major contributor of multiple infections with generation of inter subtype recombinants in our cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.