ArticleDevelopmental cell2011
Ras effector switching promotes divergent cell fates in C. elegans vulval patterning.
Article in Developmental cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Article
- Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions.Aging cell · 2026Article
- Aging, dauer, and stature phenotypes are conferred by structure-directed missense mutations in the endogenous AGE-1/phosphatidylinositol 3-kinase catalytic subunit.bioRxiv : the preprint server for biology · 2026Article
- RAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The RAL Small G Proteins Are Clinically Relevant Targets in Triple Negative Breast Cancer.Cancers · 2024Article
- Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans.Disease models & mechanisms · 2024Article
- RAL-1 signaling regulates lipid composition inmicroPublication biology · 2024Article
- Afadin couples RAS GTPases to the polarity rheostat Scribble.Nature communications · 2022Article
- A signalling cascade for Ral.Small GTPases · 2022Review
- Nuclear translocation of the tagged endogenous MAPK MPK-1 denotes a subset of activation events in C. elegans development.Journal of cell science · 2021Article
- Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.Developmental biology · 2021Article
- The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.Breast cancer research : BCR · 2021Article
- LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.Molecular biology of the cell · 2021Article
- Ras, Ral, and Rap1 in C. elegans.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Insulated Switches: Dual-Function Protein RalGEFInternational journal of molecular sciences · 2020Article
- ROS regulation of RAS and vulva development in Caenorhabditis elegans.PLoS genetics · 2020Article
- Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals.PLoS genetics · 2019Article
- The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.Journal of developmental biology · 2018Review
- Article
- Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning.Cell reports · 2018Article
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3 authors.
Funding
Abstract
The C. elegans vulva is patterned by epidermal growth factor (EGF) activation of Ras to control 1° fate, and 1° fate induces antagonistic Notch-dependent 2° fate. Furthermore, a spatial EGF gradient, in addition to inducing 1° fate, directly contributes to 2° fate via an unknown pathway. We find that in addition to its canonical effector, Raf, vulval Ras utilizes an exchange factor for the Ral small GTPase (RalGEF), such that Ras-RalGEF-Ral antagonizes Ras-Raf pro-1° fate activity. Consistent with its restricted expression pattern, Ral participates in EGF pro-2° activity. Thus, we have delineated a Ras effector-switching mechanism whereby position within the morphogen gradient dictates that Ras effector usage is switched to RalGEF from Raf to promote 2° instead of 1° fate. Our observations define the utility of Ras effector switching during normal development and may provide a possible mechanistic basis for cell and cancer-type differences in effector dependency and activation.
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