Evidence map›Paper›PMID 21238824›Full record

ReviewJournal of the American Academy of Dermatology2011

Update on morphea: part II. Outcome measures and treatment.

Nicole Fett, Victoria P Werth

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American Academy of Dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Interventions for morphea.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Pooled it
  3. Trial
  4. High-frequency ultrasound evaluation of morphea: Retrospective analytical study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  5. [Localized scleroderma].Dermatologie (Heidelberg, Germany) · 2024
    Review
  6. Recent Advances in Treatment of Systemic Sclerosis and Morphea.American journal of clinical dermatology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role of imaging in morphea assessment: A review of the literature.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Review
  12. Morphea: The 2023 update.Frontiers in medicine · 2023
    Review
  13. Article
  14. Skin sonography in children: a review.Pediatric radiology · 2022
    Review
  15. Article
  16. Article
  17. Upcoming treatments for morphea.Immunity, inflammation and disease · 2021
    Review
  18. Review
  19. Clinical Approach to Linear Hyperpigmentation: A Review Article.Clinical, cosmetic and investigational dermatology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicole FettDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Nicole.Fett@uphs.upenn.edu
Victoria P Werth
University of Pennsylvania · US

Funding

PATIENT-ORIENTED RESEARCH IN SKIN AUTOMMUNE DISEASEK24AR002207 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI WERTH, VICTORIA P · 2001 to 2012
$1.3M
NIAMS NIH HHS K24 AR002207NIAMS NIH HHS K24-AR 02207
6 · The paper itself

Abstract

Morphea is a rare fibrosing disorder of the skin and underlying tissues. The underlying pathogenesis of morphea is not completely understood at this time, but ultimately results in an imbalance of collagen production and destruction. Evidence-based treatment options of morphea are limited secondary to the rarity of the disease, and the lack of universally used validated outcome measures. The most commonly used outcome measures are skin scores, computerized surface area measurement, durometer, cutometer, thermography, and ultrasound measurements. The Localized Scleroderma Cutaneous Assessment Tool is a promising recently validated skin scoring tool that allows differentiation between activity and damage, is sensitive to change, and requires no additional equipment. The most robust data in the treatment of morphea exists for methotrexate in combination with systemic steroids and ultraviolet A1.

Indexed as

AdolescentAdultChildHumansMethotrexateMycophenolic AcidScleroderma, LocalizedSkinSteroidsTacrolimusThermographyTreatment OutcomeUltrasonographyUltraviolet TherapyValidation Studies as TopicMethotrexateMycophenolic AcidSteroidsTacrolimus

Identifiers

PMID21238824
PMCPMC7382896
OpenAlexW2767260981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.