ArticleRespiratory physiology & neurobiology2011
Potentiation of the hypoxic ventilatory response by 1 day of hyperoxia in neonatal rats.
Article in Respiratory physiology & neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Respiratory plasticity induced by chronic hyperoxia in juvenile and adult rats.Respiratory physiology & neurobiology · 2025Article
- Ventilatory and chemoreceptor responses to hypercapnia in neonatal rats chronically exposed to moderate hyperoxia.Respiratory physiology & neurobiology · 2017Article
- Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia.Respiratory physiology & neurobiology · 2014Article
- Chronic hyperoxia and the development of the carotid body.Respiratory physiology & neurobiology · 2013Review
- Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The O(2) sensitivity of the neonatal rat carotid body is increased after 1 day in moderate hyperoxia (60% O(2)) (Donnelly et al., 2009). We investigated whether this enhanced peripheral chemosensitivity increases the hypoxic ventilatory response (HVR) and tested the hypothesis that this plasticity is mediated by the superoxide anion. Neonatal rats (7 d old) were injected with saline or MnTMPyP, a superoxide scavenger, and placed into 60% O(2) for 23-28h. Baseline ventilation was reduced and the acute HVR (12% O(2)) was enhanced in hyperoxia-treated rats relative to age-matched controls; MnTMPyP did not block these effects. An additional group of rats was studied after only 30min in 60% O(2). This shorter exposure had no effect on normoxic ventilation or the HVR. We conclude that 1 d, but not 30min, of 60% O(2) augments the HVR of neonatal rats and that production of the superoxide anion does not contribute to this plasticity.
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