ArticleMolecular and cellular endocrinology2011
Progesterone induces expression of the prolactin receptor gene through cooperative action of Sp1 and C/EBP.
Article in Molecular and cellular endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Activation of Genes by Nuclear Receptor/Specificity Protein (Sp) Interactions in Cancer.Cancers · 2025Review
- Prolactin drives cortical neuron maturation and dendritic development during murine embryonic stem cell differentiation.Frontiers in cell and developmental biology · 2025Article
- How Protein Methylation Regulates Steroid Receptor Function.Endocrine reviews · 2022Review
- Prolactin receptor gene transcriptional control, regulatory modalities relevant to breast cancer resistance and invasiveness.Frontiers in endocrinology · 2022Review
- Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.Frontiers in cell and developmental biology · 2021Article
- Article
- Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism.iScience · 2019Article
- Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.Journal of neuroendocrinology · 2019Article
- Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation.Journal of mammary gland biology and neoplasia · 2015Review
- Article
- Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction.Chinese journal of integrative medicine · 2015Article
- A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells.Journal of cellular and molecular medicine · 2014Article
- Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor.The Journal of biological chemistry · 2014Article
- Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.Endocrine reviews · 2013Review
- Progesterone receptors, their isoforms and progesterone regulated transcription.Molecular and cellular endocrinology · 2012Review
- Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.Nature medicine · 2012Article
- Mitochondria-localized glutamic acid-rich protein (MGARP) gene transcription is regulated by Sp1.PloS one · 2012Article
- Article
- Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1).The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Prolactin (Prl) and progesterone (P) cooperate synergistically during mammary gland development and tumorigenesis. We hypothesized that one mechanism for these effects may be through mutual induction of receptors (R). EpH4 mouse mammary epithelial cells stably transfected with PR-A express elevated levels of PrlR mRNA and protein compared to control EpH4 cells that lack the PR. Likewise, T47D human breast cancer cells treated with P overexpress the PrlR and activate PrlR promoter III. PrlR promoter III does not contain a classical P response element but contains several binding sites for transcription proteins, including C/EBP, Sp1 and AP1, which may also interact with the PR. Using promoter deletion and site directed mutagenesis analyses as well as gel shift assays, cooperative activation of the C/EBP and adjacent Sp1A, but not the Sp1B or AP1, sites by P is shown to confer P responsiveness leading to increased PrlR transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.