ReviewJournal of controlled release : official journal of the Controlled Release Society2011
Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends.
Review in Journal of controlled release : official journal of the Controlled Release Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07615959 (Clinical Investigation to Evaluate the Safety, Tolerability and Performance of the Medicsen Smartpatch, a Non-Invasive Ultrasound-Based Drug Delivery Medical Device), which is not on this map. Cited by 142 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Investigation to Evaluate the Safety, Tolerability and Performance of the Medicsen Smartpatch, a Non-Invasive Ultrasound-Based Drug Delivery Medical Device (SOUNDD Study)
Who cites it
142 citing papers in PubMed, 2 syntheses or guidelines pooled it, 424 citations in OpenAlex.
- Transdermal Iontophoresis Insulin in Laboratory Animals: A Systematic Review.Iranian biomedical journal · 2025Pooled it
- A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic.Theranostics · 2023Pooled it
- Dexamethasone Sodium Phosphate Penetration During Phonophoresis at 2 Ultrasound Frequencies.Journal of athletic training · 2020Trial
- The pulsed ultrasound strategy effectively decreases the S. aureus population of chronic rhinosinusitis patients.BMC research notes · 2019Trial
- Systemic Copper Chelation Reduces Collagen Deposition and Preserves Secretory Function in Irradiated Mouse Salivary Glands.Advances in radiation oncology · 2026Article
- Review
- Microbubble-free mechanical sonoporation for MR-guided drug delivery in solid tumours: a proof-of-concept study.Drug delivery and translational research · 2026Article
- A comprehensive review of thermal ablation technologies for transdermal drug delivery: mechanisms, commercial products, and future smart systems.Drug delivery and translational research · 2026Review
- Advances in veterinary drug and vaccine delivery: from conventional delivery methods to innovative transdermal approaches.Drug delivery and translational research · 2026Review
- Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment.Bioactive materials · 2026Review
- Revealing biomechanical vulnerabilities in oral cancer cells using 3D coculture platform and low-frequency ultrasound.Materials today. Bio · 2026Article
- Low-intensity transcranial ultrasound neuromodulation promotes neuronal regeneration: A new hope for noninvasive treatment of neurodegenerative diseases.Neural regeneration research · 2026Article
- Transdermal needle-free drug delivery approaches and activation mechanism.Materials today. Bio · 2026Review
- Microdermabrasion with Calcium Hydrogen Phosphate for Enhancing Skin Permeation of Lidocaine-tetracaine Eutectic Microemulsion Gel.Pharmaceutical research · 2026Article
- In Vivo Indirect Insulin Dose Evaluation of Noninvasive Ultrasound-Mediated Transdermal Delivery Compared to Subcutaneous Injection.Biomedicines · 2026Article
- Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Sequential drug release from dual-responsive scaffold with ultrasound-enhanced efficacy for infectious oral ulcer therapy.Regenerative biomaterials · 2026Article
- Effectiveness of free vastus lateralis musculocutaneous flap transplantation plus ultrasound-mediated transdermal Qianjin Weijing decoction for chronic empyema: a prospective, preference-based observational study.Frontiers in medicine · 2026Article
- Near-infrared light-activated lidocaine microneedle patch for rapid local anesthesia.Theranostics · 2026Article
- Impact of moisturizing pretreatments on small reusable dental instruments cleanliness and mechanics.PloS one · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥0.7MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20-100kHz) has only been investigated significantly during the past two decades. Although HFS and LFS are similar because they both utilize ultrasound to increase the skin penetration of permeants, the mechanisms associated with each physical enhancer are different. Specifically, the location of cavitation and the extent to which each process can increase skin permeability are quite dissimilar. Although the applications of both technologies are different, they each have strengths that could allow them to improve current methods of local, regional, and systemic drug delivery. In this review, we will discuss the mechanisms associated with both HFS and LFS, specifically concentrating on the key mechanistic differences between these two skin treatment methods. Background on the relevant physics associated with ultrasound transmitted through aqueous media will also be discussed, along with implications of these phenomena on sonophoresis. Finally, a thorough review of the literature is included, dating back to the first published reports of sonophoresis, including a discussion of emerging trends in the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.