ArticleDevelopmental biology2011
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2026Article
- Transcriptomic Analysis ofbioRxiv : the preprint server for biology · 2026Article
- Origin, fate and function of extraembryonic tissues during mammalian development.Nature reviews. Molecular cell biology · 2025Review
- Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction.Molecular medicine (Cambridge, Mass.) · 2023Article
- The impact of bisphenol A on the placenta†.Biology of reproduction · 2022Article
- In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring.Experimental physiology · 2022Review
- Histology Atlas of the Developing Mouse Placenta.Toxicologic pathology · 2022Article
- ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Vaginal Exposure toFrontiers in microbiology · 2021Article
- Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2.BMC biology · 2020Article
- Placental imprinting: Emerging mechanisms and functions.PLoS genetics · 2020Review
- Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- TNFα-induced Up-regulation ofAging and disease · 2019Article
- miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.Developmental biology · 2019Article
- Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage.PLoS genetics · 2018Article
- Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models.Frontiers in endocrinology · 2018Review
- Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.Frontiers in molecular neuroscience · 2018Article
- Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.Molecular and clinical oncology · 2017Article
- Transplacental Nutrient Transport Mechanisms of Intrauterine Growth Restriction in Rodent Models and Humans.Frontiers in physiology · 2017Review
- Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta.Developmental biology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Several imprinted genes have been implicated in the regulation of placental function and embryonic growth. On distal mouse chromosome 7, two clusters of imprinted genes, each regulated by its own imprinting center (IC), are separated by a poorly characterized region of 280kb (the IC1-IC2 interval). We previously generated a mouse line in which this IC1-IC2 interval has been deleted (Del(7AI) allele) and found that maternal inheritance of this allele results in low birth weights in newborns. Here we report that Del(7AI) causes a partial loss of Ascl2, a maternally expressed gene in the IC2 cluster, which when knocked out leads to embryonic lethality at midgestation due to a lack of spongiotrophoblast formation. The hypomorphic Ascl2 allele causes embryonic growth restriction and an associated placental phenotype characterized by a reduction in placental weight, reduced spongiotrophoblast population, absence of glycogen cells, and an expanded trophoblast giant cell layer. We also uncovered severe defects in the labyrinth layer of maternal mutants including increased production of the trilaminar labyrinth trophoblast cell types and a disorganized labyrinthine vasculature. Our results have important implications for our understanding of the role played by the spongiotrophoblast layer during placentation and show that regulation of the dosage of the imprinted gene Ascl2 can affect all three layers of the chorio-allantoic placenta.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.