ArticleComparative immunology, microbiology and infectious diseases2011
Transient or persistent norovirus infection does not alter the pathology of Salmonella typhimurium induced intestinal inflammation and fibrosis in mice.
Article in Comparative immunology, microbiology and infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of maternal overnutrition and metabolic challenge in adult life on the histological integrity of the liver and intestinal epithelium in rabbits.Frontiers in nutrition · 2025Article
- Impact of the Microbiota on Viral Infections.Annual review of virology · 2023Review
- Potential Role of Epithelial Endoplasmic Reticulum Stress and Anterior Gradient Protein 2 Homologue in Crohn's Disease Fibrosis.Journal of Crohn's & colitis · 2021Article
- Lack of Effect of Murine Norovirus Infection on the CD4Comparative medicine · 2020Article
- Development and evaluation of a broadly reactive reverse transcription recombinase polymerase amplification assay for rapid detection of murine norovirus.BMC veterinary research · 2018Article
- Natural Secretory Immunoglobulins Promote Enteric Viral Infections.Journal of virology · 2018Article
- Optimisation of Intestinal Fibrosis and Survival in the Mouse S. Typhimurium Model for Anti-fibrotic Drug Discovery and Preclinical Applications.Journal of Crohn's & colitis · 2017Article
- Histologic Lesions Induced by Murine Norovirus Infection in Laboratory Mice.Veterinary pathology · 2016Review
- Viruses in Rodent Colonies: Lessons Learned from Murine Noroviruses.Annual review of virology · 2015Review
- Murine Norovirus Infection Variably Alters Atherosclerosis in Mice Lacking Apolipoprotein E.Comparative medicine · 2015Article
- Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia.Veterinary research · 2015Article
- Ultrasound shear wave elastography helps discriminate low-grade from high-grade bowel wall fibrosis in ex vivo human intestinal specimens.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2014Article
- Infection with murine norovirus 4 does not alter Helicobacter-induced inflammatory bowel disease in Il10(-/-) mice.Comparative medicine · 2014Article
- A broadly reactive one-step SYBR Green I real-time RT-PCR assay for rapid detection of murine norovirus.PloS one · 2014Article
- Murine noroviruses bind glycolipid and glycoprotein attachment receptors in a strain-dependent manner.Journal of virology · 2012Article
- Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "Top-Down" approach to intestinal fibrosis in mice.Inflammatory bowel diseases · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Murine noroviruses (MNV) are currently the most prevalent viruses infecting mouse research colonies. Concurrent infection of research mice with these viruses can dramatically alter the experimental outcome in some research models, but not others. In this report, we investigated the effect of MNV1 and MNV4 on a murine model of intestinal inflammation and fibrosis induced by Salmonella typhimurium infection in C57BL/6 mice. Subsequent co-infection of these mice with MNV1 or MNV4 did not lead to major changes in histopathology, the inflammatory response, or the fibrotic response. Thus, MNV does not substantially alter all gastrointestinal research models, highlighting the importance of investigating potential alterations in the research outcome by MNV on an individual basis. We hypothesize that this is particularly important in cases of research models that use immunocompromised mice, which could be more sensitive to MNV infection-induced changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.