ArticleCurrent biology : CB2011
Transcriptional profiling identifies TNS4 function in epithelial tubulogenesis.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Epithelial tubule interconnection driven by HGF-Met signaling in the kidney.bioRxiv : the preprint server for biology · 2024Article
- Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.International journal of biological sciences · 2024Article
- The postbiotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cells.Frontiers in nutrition · 2024Article
- Tensins in Kidney Function and Diseases.Life (Basel, Switzerland) · 2023Review
- Immunohistochemical Expression of Tensin-4/CTEN in Squamous Cell Carcinoma in Dogs.Veterinary sciences · 2023Article
- RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.World journal of gastrointestinal oncology · 2022Article
- Increased tensin 4 expression is related to the histological type of gastric cancer.World journal of clinical oncology · 2021Article
- Article
- Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles.Scientific reports · 2019Article
- Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.Journal of cell science · 2016Article
- Multiple pathways regulate Cten in colorectal cancer without a Tensin switch.International journal of experimental pathology · 2015Article
- C-terminal tensin-like (CTEN): a promising biomarker and target for cancer.The international journal of biochemistry & cell biology · 2014Review
- Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells.Developmental cell · 2014Article
- Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth.Current biology : CB · 2014Article
- Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8.American journal of physiology. Cell physiology · 2013Article
- Polarity in mammalian epithelial morphogenesis.Cold Spring Harbor perspectives in biology · 2013Review
- EB1-recruited microtubule +TIP complexes coordinate protrusion dynamics during 3D epithelial remodeling.Current biology : CB · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Hepatocyte growth factor (HGF) plays central roles in tubulogenesis and metastasis [1-4]. HGF treatment of Madin-Darby canine kidney (MDCK) cells grown as cysts in three-dimensional culture induces tubulogenesis [5, 6], which like most tubulogenic processes proceeds through distinct intermediate phases. Identification of genes associated with these phases is central to understanding the molecular mechanisms of tubulogensis; however, because of inefficient, asynchronous tubule formation, isolating such genes has been unfeasible. Here we developed a synchronous, efficient tubulogenesis system and used time-course transcriptional profiling to identify genes temporally regulated in developmental intermediates. Knockdown (KD) of tensin 4 (TNS4), a particularly highly upregulated gene, leads to a decrease in formation of extensions and tubules, two sequential intermediates in tubulogenesis. Exogenous expression of TNS4 marks invasive cells in an epithelial sheet. A mutation in the SH2 domain of TNS4 prevents the transition from extension formation to invasive migration during tubule formation and leads to increased basal activation of STAT3. Exogenous expression of a constitutively active STAT3 mimics the defect by the mutation. Our study highlights the role of the TNS4-STAT3 axis in epithelial sheet invasion and tubulogenesis.
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Registered trials
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