ReviewCurrent opinion in immunology2011
Molecular resolution of the B cell landscape.
Review in Current opinion in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- miRNA-mRNA network analysis identifies PAX5 as a potential regulator of adaptive immune response in COPD.bioRxiv : the preprint server for biology · 2025Article
- Association of Wiskott-Aldrich syndrome protein (WASp) in epigenetic regulation of B cell differentiation in non-small-cell lung cancer (NSCLC).Medical oncology (Northwood, London, England) · 2023Article
- High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia.Oncotarget · 2016Article
- ncRNA-regulated immune response and its role in inflammatory lung diseases.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Chromatin and transcriptional tango on the immune dance floor.Frontiers in immunology · 2014Article
- Article
- The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.Nature immunology · 2013Article
- A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.Nucleic acids research · 2012Article
- Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells.Cytokine · 2012Review
- Transcriptional and epigenetic regulation of B cell development.Immunologic research · 2011Review
- The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells.International immunology · 2011Article
- E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.Blood · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires that uncommitted progenitors successfully negotiate the transition from multipotency to unipotency, including the loss of self-renewal potential. Previous work identified essential transcription factors that mediate B lineage development. Major advances build on this knowledge and reveal coordinated changes in gene expression occurring within single cells at sequential stages in the B cell differentiation pathway. Recent studies on epigenetic mechanisms also provide a framework within which transcription factor activity, chromatin modifications, and gene expression patterns can be viewed at hierarchical levels to link genotype and phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.