ReviewNeurobiology of learning and memory2011
Bidirectional metabolic regulation of neurocognitive function.
Review in Neurobiology of learning and memory, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- The Neuronal Actions of Leptin and the Implications for Treating Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Associations of Objectively-Assessed Physical Activity and Sedentary Time with Hippocampal Gray Matter Volume in Children with Overweight/Obesity.Journal of clinical medicine · 2020Article
- Article
- A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Cafeteria-diet induced obesity results in impaired cognitive functioning in a rodent model.Heliyon · 2019Article
- Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- RNA-Sequencing ofG3 (Bethesda, Md.) · 2018Article
- Regulation of Hippocampal Synaptic Function by the Metabolic Hormone, Leptin: Implications for Health and Neurodegenerative Disease.Frontiers in cellular neuroscience · 2018Review
- Review
- Amylin-mediated control of glycemia, energy balance, and cognition.Physiology & behavior · 2016Review
- Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Models and mechanisms for hippocampal dysfunction in obesity and diabetes.Neuroscience · 2015Review
- Minireview: Food for thought: regulation of synaptic function by metabolic hormones.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats.Brain research bulletin · 2014Article
- Effects of diet on brain plasticity in animal and human studies: mind the gap.Neural plasticity · 2014Review
- Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging.Frontiers in aging neuroscience · 2014Article
- Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression.Neurobiology of learning and memory · 2012Article
- Selective breeding for endurance running capacity affects cognitive but not motor learning in rats.Physiology & behavior · 2012Article
- Leptin: a novel therapeutic target in Alzheimer's disease?International journal of Alzheimer's disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The efficiency of somatic energy metabolism is correlated with cognitive change over the lifespan. This relationship is bidirectional, with improved overall fitness associated with enhanced synaptic function and neuroprotection, and synaptic endangerment occurring in the context of impaired energy metabolism. In this review, we discuss recent advancements in the fields of exercise, dietary energy intake and diabetes, as they relate to neuronal function in the hippocampus. Because hippocampal neurons have energy requirements that are relatively higher than those of other brain regions, they are uniquely poised to benefit from exercise, and to be harmed by diabetes. We view exercise and dietary energy restriction as being associated with enhanced hippocampal plasticity at one end of a continuum, with obesity and diabetes accompanied by cognitive impairment at the other end of the continuum. Understanding the mechanisms for this continuum may yield novel therapeutic targets for the prevention and treatment of cognitive decline following aging, disease, or injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.