Trial reportFree radical biology & medicine2011
Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans.
Trial report in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Increased endothelial microparticles and oxidative stress at extreme altitude.European journal of applied physiology · 2016Trial
- Fat Oxidation of Fatty Fish vs. Meat Meal Diets UnderFrontiers in nutrition · 2022Article
- High-Dose Vitamin C in Advanced-Stage Cancer Patients.Nutrients · 2021Review
- Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk.International journal of molecular sciences · 2021Observational
- Vitamin C Activates the Folate-Mediated One-Carbon Cycle in C2C12 Myoblasts.Antioxidants (Basel, Switzerland) · 2020Article
- Obesity, cardiovascular disease, and role of vitamin C on inflammation: a review of facts and underlying mechanisms.Inflammopharmacology · 2017Review
- Article
- Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- A simple method for plasma total vitamin C analysis suitable for routine clinical laboratory use.Nutrition journal · 2016Article
- Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes.Iranian biomedical journal · 2014Article
- Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.Antioxidants & redox signaling · 2013Review
- Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013Review
- Vitamins C and E: beneficial effects from a mechanistic perspective.Free radical biology & medicine · 2011Review
- Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants.Inhalation toxicologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The lack of suitable biomarkers of oxidative stress is a common problem for antioxidant intervention studies in humans. We evaluated the efficacy of vitamin C supplementation in decreasing biomarkers of lipid peroxidation in nonsmokers and in cigarette smokers, a commonly studied, free-living human model of chronic oxidative stress. Participants received ascorbic acid (500mg twice per day) or placebo for 17 days in a double-blind, placebo-controlled, randomized crossover design study. The urinary biomarkers assessed and reported herein are derived from 4-hydroperoxy-2-nonenal (HPNE) and include the mercapturic acid (MA) conjugates of 4-hydroxy-2(E)-nonenal (HNE), 1,4-dihydroxy-2(E)-nonene (DHN), and 4-oxo-2(E)-nonenol(ONO). Vitamin C supplementation decreased the urinary concentrations of both ONO-MA (p=0.0013) and HNE-MA (p=0.0213) by ~30%; however, neither cigarette smoking nor sex affected these biomarkers. In contrast, vitamin C supplementation decreased urinary concentrations of DHN-MA (three-way interaction p=0.0304) in nonsmoking men compared with nonsmoking women (p<0.05), as well as in nonsmoking men compared with smoking men (p<0.05). Vitamin C supplementation also decreased (p=0.0092) urinary total of metabolites by ~20%. Thus, HPNE metabolites can be reduced favorably in response to improved plasma ascorbic acid concentrations, an effect due to ascorbic acid antioxidant function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.