Evidence map›Paper›PMID 21235825›Full record

Trial reportBMC public health2011

Prevention of type 2 diabetes in a primary healthcare setting: three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance.

Naoki Sakane, Juichi Sato, Kazuyo Tsushita, Satoru Tsujii, Kazuhiko Kotani, Kokoro Tsuzaki, Makoto Tominaga, Shoji Kawazu, Yuzo Sato, Takeshi Usui and 6 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06958640 (Da Qing Offspring Study), which is not on this map. Cited by 66 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 17 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06958640 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Da Qing Offspring Study

TypeobservationalSponsorChina-Japan Friendship HospitalRan2025 to 2026Enrolled5,000ConditionsDiabetes Mellitus, Cardiovascular Diseases (CVD), Offspring, Adult, Impaired Glucose Tolerance (Prediabetes)ArmsLifestyle interventions
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 17 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

Naoki SakaneDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. nsakane@kyotolan.hosp.go.jp
Juichi Sato
Kazuyo Tsushita
Satoru Tsujii
Kazuhiko Kotani
Kokoro Tsuzaki
Makoto Tominaga
Shoji Kawazu
Yuzo Sato
Takeshi Usui
Isao Kamae
Toshihide Yoshida
Yutaka Kiyohara
Shigeaki Sato
Hideshi Kuzuya
Japan Diabetes Prevention Program (JDPP) Research Group
Kyoto Medical Center · JPAichi Gakuin University · JPAichi Health Promotion Foundation · JPAino University · JPInstitute for Adult Diseases Asahi Life Foundation · JPKeio University Shonan Fujisawa · JPKyoto City Hospital · JPNagoya University Hospital · JPNational Hospital Organization Hanamaki Hospital · JPTakeda (Japan) · JPTenri Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA randomized control trial was performed to test whether a lifestyle intervention program, carried out in a primary healthcare setting using existing resources, can reduce the incidence of type 2 diabetes in Japanese with impaired glucose tolerance (IGT). The results of 3 years' intervention are summarized.

methodsThrough health checkups in communities and workplaces, 304 middle-aged IGT subjects with a mean body mass index (BMI) of 24.5 kg/m2 were recruited and randomized to the intervention group or control group. The lifestyle intervention was carried out for 3 years by public health nurses using the curriculum and educational materials provided by the study group.

resultsAfter 1 year, the intervention had significantly improved body weight (-1.5 ± 0.7 vs. -0.7 ± 2.5 kg in the control; p = 0.023) and daily non-exercise leisure time energy expenditure (25 ± 113 vs. -3 ± 98 kcal; p = 0.045). Insulin sensitivity assessed by the Matsuda index was improved by the intervention during the 3 years. The 3-year cumulative incidence tended to be lower in the intervention group (14.8% vs.8.2%, log-rank test: p = 0.097). In a sub-analysis for the subjects with a BMI > 22.5 kg/m2, a significant reduction in the cumulative incidence was found (p = 0.027).

conclusionsThe present lifestyle intervention program using existing healthcare resources is beneficial in preventing diabetes in Japanese with IGT. This has important implications for primary healthcare-based diabetes prevention. TRIAL REGISTRATION NUMBER: UMIN000003136.

Indexed as

Life StyleAdultBlood GlucoseBody Mass IndexBody WeightCommunity Health ServicesComparative Effectiveness ResearchDiabetes Mellitus, Type 2Energy MetabolismFemaleFollow-Up StudiesGlucose IntoleranceGlucose Tolerance TestHealth PromotionHumansInsulinBlood GlucoseInsulin

Identifiers

PMID21235825
PMCPMC3037863
OpenAlexW1984638641

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.