ArticleClinical and experimental immunology2011
Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases.
Article in Clinical and experimental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02993302 (Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Gene polymorphisms of pro-inflammatory cytokines may affect the risk of Graves' disease: a meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Immune System-Related Genetic Risk Factors for Inhibitory Antibody Development in Patients With Hemophilia: Reviewing an Old Problem From a New Perspective-A Narrative Review.Health science reports · 2025Article
- Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave's disease and control.BMC molecular and cell biology · 2025Article
- Multiple sclerosis susceptibility may be associated with the coding rs20541 (R130Q) IL-13 gene polymorphism in the Polish population.Scientific reports · 2023Article
- Comprehensive analysis of chemokine gene polymorphisms in Korean children with autoimmune thyroid disease.Scientific reports · 2023Article
- Association of ITM2A rs1751094 polymorphism on X chromosome in Korean pediatric patients with autoimmune thyroid disease.Immunity, inflammation and disease · 2023Article
- Th2 Cytokines (Interleukin-5 and -9) Polymorphism Affects the Response to Anti-TNF Treatment in Polish Patients with Ankylosing Spondylitis.International journal of molecular sciences · 2022Article
- Associations between gut microbiota and thyroidal function status in Chinese patients with Graves' disease.Journal of endocrinological investigation · 2021Article
- Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves' Disease.Frontiers in endocrinology · 2021Article
- Article
- Association between polymorphism within interleukin related genes and Graves' disease: a meta-analysis of 22 case-control studies.Oncotarget · 2017Article
- The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.Clinical and experimental immunology · 2014Article
- Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases.Clinical and experimental immunology · 2014Article
- Interleukins as markers of inflammation in malignant and benign thyroid disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Association of IL-13 single nucleotide polymorphisms in Iranian patients to multiple sclerosis.American journal of clinical and experimental immunology · 2014Article
- Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease.PloS one · 2014Article
- Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies.Journal of clinical immunology · 2012Article
- Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves' disease and Graves' ophthalmopathy.BMC medical genetics · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the association of genetic producibility of interleukin (IL)-5, IL-6 and IL-13, which are secreted by T helper type 2 (Th2), with the development and prognosis of autoimmune thyroid disease (AITD), we genotyped IL5-746C/T, IL6-572C/G and IL13-1112C/T polymorphisms, which are functional polymorphisms in the promoter regions of the genes regulating these cytokines. Fifty-seven patients with intractable Graves' disease (GD), 52 with GD in remission, 52 with severe Hashimoto's disease (HD), 56 with mild HD and 91 healthy controls were examined in this study. The IL13-1112T allele, which correlates with higher producibility of IL-13, was more frequent in patients with GD in remission than in those with intractable GD [P=0·009, odds ratio (OR)=3·52]. The IL5-746T allele, which may correlate with lower levels of IL-5, was more frequent in patients with GD in remission than controls (P=0·029, OR=2·00). The IL6-572G allele carriers (CG and GG genotypes), which have higher producibility of IL-6, were more frequent in AITD patients (P=0·033, OR=1·75), especially in GD in remission (P=0·031, OR=2·16) and severe HD (P=0·031, OR=2·16) than in controls. Interestingly, both allele and genotype frequencies of Th2 cytokine genes were similar between GD and HD patients. In conclusion, functional polymorphisms in the genes encoding Th2 cytokines are associated differently with the development and prognosis of AITD from each other.
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