ArticleJournal of computational neuroscience2011
Interactions of persistent sodium and calcium-activated nonspecific cationic currents yield dynamically distinct bursting regimes in a model of respiratory neurons.
Article in Journal of computational neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Dynamics of ramping bursts in a respiratory neuron model.Journal of computational neuroscience · 2022Article
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- Organization of the core respiratory network: Insights from optogenetic and modeling studies.PLoS computational biology · 2018Article
- Timescales and Mechanisms of Sigh-Like Bursting and Spiking in Models of Rhythmic Respiratory Neurons.Journal of mathematical neuroscience · 2017Article
- Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model.Journal of neurophysiology · 2017Article
- A balance of outward and linear inward ionic currents is required for generation of slow-wave oscillations.Journal of neurophysiology · 2017Article
- Computational models of the neural control of breathing.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Multiple timescale mixed bursting dynamics in a respiratory neuron model.Journal of computational neuroscience · 2016Article
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network.eLife · 2016Article
- Functional Interactions between Mammalian Respiratory Rhythmogenic and Premotor Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Emergent Network Topology within the Respiratory Rhythm-Generating Kernel Evolved In Silico.PloS one · 2016Article
- Robust network oscillations during mammalian respiratory rhythm generation driven by synaptic dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The role of linear and voltage-dependent ionic currents in the generation of slow wave oscillations.Journal of computational neuroscience · 2014Article
- Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.American journal of physiology. Cell physiology · 2014Article
- Rhythmic bursting in the pre-Bötzinger complex: mechanisms and models.Progress in brain research · 2014Article
- Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Bötzinger complex neurons.Journal of computational neuroscience · 2013Article
- Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBötzinger complex).The Journal of physiology · 2013Article
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3 authors.
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Abstract
The preBötzinger complex (preBötC) is a heterogeneous neuronal network within the mammalian brainstem that has been experimentally found to generate robust, synchronous bursts that drive the inspiratory phase of the respiratory rhythm. The persistent sodium (NaP) current is observed in every preBötC neuron, and significant modeling effort has characterized its contribution to square-wave bursting in the preBötC. Recent experimental work demonstrated that neurons within the preBötC are endowed with a calcium-activated nonspecific cationic (CAN) current that is activated by a signaling cascade initiated by glutamate. In a preBötC model, the CAN current was shown to promote robust bursts that experience depolarization block (DB bursts). We consider a self-coupled model neuron, which we represent as a single compartment based on our experimental finding of electrotonic compactness, under variation of g (NaP), the conductance of the NaP current, and g (CAN), the conductance of the CAN current. Varying these two conductances yields a spectrum of activity patterns, including quiescence, tonic activity, square-wave bursting, DB bursting, and a novel mixture of square-wave and DB bursts, which match well with activity that we observe in experimental preparations. We elucidate the mechanisms underlying these dynamics, as well as the transitions between these regimes and the occurrence of bistability, by applying the mathematical tools of bifurcation analysis and slow-fast decomposition. Based on the prevalence of NaP and CAN currents, we expect that the generalizable framework for modeling their interactions that we present may be relevant to the rhythmicity of other brain areas beyond the preBötC as well.
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